Cytotoxic constituents of the stems of Cinnamomum subavenium

被引：56
作者：
Chen, Chung-Yi [1 ]
Chen, Ching-Hsein
Wong, Chung-Hang
Liu, Yi-Wen
Lin, Yu-Shan
Wang, Yau-Der
Hsui, Yen-Ray
机构：
[1] Fooyin Univ, Basic Med Sci Educ Ctr, Kaohsiung 831, Taiwan
[2] Natl Chiayi Univ, Coll Life Sci, Grad Inst Biopharmaceut, Chiayi 600, Taiwan
[3] Chang Gung Inst Technol, Chang Gung Mem Hosp, Dept Anesthesiol, Chiayi 613, Taiwan
[4] Chang Gung Inst Technol, Chiayi Sch, Chiayi 613, Taiwan
[5] Fooyin Univ, Dept Med Technol, Kaohsiung 831, Taiwan
[6] Taiwan Forestry Res Inst, Div Silviculture, Taipei 100, Taiwan
来源：
JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 01期
关键词：
D O I：
10.1021/np060425k
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The aim of this study was to evaluate the cytotoxic effects of three new butanolides, subamolides A-C (1-3), and a new secobutanolide, secosubamolide (4), on the human colorectal cancer cell line SW480. Compounds 1-4are new and were isolated from the stems of Cinnamomum subavenium, along with 17 known compounds. The structures of 1-4 were determined by spectroscopic analysis. Propidium iodide staining and flow cytometry were used to evaluate DNA damage of the treated SW480 cells, and it was found that 1-4 caused DNA damage in a dose-dependent manner after 24 h of treatment.
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页码：103 / 106
页数：4
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