Decreased level of kynurenic acid in cerebrospinal fluid of relapsing-onset multiple sclerosis patients

被引：89
|
作者：
Rejdak, K
Bartosik-Psujek, H
Dobosz, B
Kocki, T
Grieb, P
Giovannoni, G
Turski, WA
Stelmasiak, Z
机构：
[1] Med Univ, Dept Neurol, PL-20090 Lublin, Poland
[2] Med Univ, Dept Pharmacol, PL-20090 Lublin, Poland
[3] Inst Agr Med, Dept Toxicol, Lublin, Poland
[4] Polish Acad Sci, Lab Expt Pharmacol, Med Res Ctr, Warsaw, Poland
[5] Inst Neurol, Neuroimmunol Unit, London WC1N 3BG, England
来源：
NEUROSCIENCE LETTERS | 2002年 / 331卷 / 01期
关键词：
kynurenic acid; cerebrospinal fluid; multiple sclerosis; human;
D O I：
10.1016/S0304-3940(02)00710-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study was undertaken to measure cerebrospinal fluid (CSF) levels of kynurenic acid (KYNA) in patients with relapsing-onset multiple sclerosis (MS) during remission or not progressing for at least 2 months. In these patients the levels of CSF KYNA were found to be significantly lower compared with subjects with non-inflammatory neurological diseases, as well as those with inflammatory disease (median (interquartile range): 0.41 (0.3-0.5) pmol/ml, n = 26 vs. 0.67 (0.5-1.1), n = 23, P < 0.01 and 1.7 (1.5-2.6), n = 16, P < 0.001, respectively). These results provide further evidence of the alterations in the kynurenine pathway during remitting-onset MS. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：63 / 65
页数：3
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