Cobalt(II)-Catalyzed C-H/N-H Functionalization and Annulation of N-(quinolin-8-yl)benzamide with Cyclopropanols

被引：13
作者：
Chen, Jinkang [2 ]
Yin, Chuanliu [1 ]
Zhou, Jian [1 ]
Yu, Chuanming [1 ,2 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Peoples R China
[2] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Annulation; C-H functionalization; Co(II) catalysis; Cyclopropanols; Isoindolin-1-ones;
D O I：
10.1002/ejoc.202001302
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for Co-catalyzed C-H/N-H functionalization and [4+1] annulation of N-(quinolin-8-yl)benzamide with cyclopropanols was developed. This protocol tolerates a variety of functional groups, thereby providing an efficient method for the fabrication of isoindolin-1-ones. Moreover, the utility of this strategy was showcased by the late-stage modification of lithocholic acid derivatives and ibuprofen derivatives.
引用
收藏
页码：915 / 923
页数：9
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