Cobalt(II)-Catalyzed C-H/N-H Functionalization and Annulation of N-(quinolin-8-yl)benzamide with Cyclopropanols

被引：15

作者：

Chen, Jinkang ^{[2
]}

Yin, Chuanliu ^{[1
]}

Zhou, Jian ^{[1
]}

Yu, Chuanming ^{[1
,2
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Peoples R China

[2] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Annulation; C-H functionalization; Co(II) catalysis; Cyclopropanols; Isoindolin-1-ones;

D O I：

10.1002/ejoc.202001302

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for Co-catalyzed C-H/N-H functionalization and [4+1] annulation of N-(quinolin-8-yl)benzamide with cyclopropanols was developed. This protocol tolerates a variety of functional groups, thereby providing an efficient method for the fabrication of isoindolin-1-ones. Moreover, the utility of this strategy was showcased by the late-stage modification of lithocholic acid derivatives and ibuprofen derivatives.

引用

页码：915 / 923

页数：9

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