Role of Honey and Acetic Acid in Mitigating the Effects of Button Battery in Esophageal Mucosa: A Cadaveric Animal Model Experimental Study

被引:6
作者
Gyawali, Bigyan Raj [1 ]
Guragain, Rajendra [1 ]
Gyawali, Dhruba Raj [2 ]
机构
[1] Inst Med, Dept ENT HNS, Maharajgunj Med Campus,Maharajgunj Rd, Kathmandu 44600, Nepal
[2] West Point Sch, Dept Sci & Res, Chandragiri 3, Kathmandu, Nepal
关键词
Button battery; Honey; Acetic acid;
D O I
10.1007/s12070-021-02382-6
中图分类号
R61 [外科手术学];
学科分类号
摘要
The objective of our study was to evaluate the role of honey and acetic acid in mitigating the mucosal injury posed by button battery using esophagus specimens from goat cadavers. This was an in vitro experimental cadaveric animal model laboratory study. We used 40 specimens of cadaveric goat esophagus and divided into four groups (A, B, C and D). The first comparison was between group A (specimens with button battery only) and group B (specimens with button battery coated with honey) for the difference in the degree of mucosal injury and change in pH and temperature. The second comparison was between group C (specimens with button battery removed after six hours) and group D (specimens with 5% acetic acid applied following the removal of the battery after six hours) for the difference in the progression of the mucosal injury and change in pH and temperature. The observer was blinded regarding the allocation of the groups. We used Fisher's exact test and independent sample t-test, to evaluate the statistical association. There was a statistically significant reduction in the degree of mucosal injury in specimens applied with button battery coated with honey compared to the specimens applied with button battery only. Similarly, progression of the mucosal injury was halted in specimens with the application of acetic acid following the removal of the button battery. Honey and acetic acid can mitigate the mucosal effects posed by the button battery in cadaveric goat esophageal specimens.
引用
收藏
页码:5759 / 5765
页数:7
相关论文
共 16 条
[1]  
Anfang RR, 2019, LARYNGOSCOPE, V129, P49, DOI 10.1002/lary.27312
[2]   Clinical Profile and Outcome of Esophageal Button Battery Ingestion in Children: An 8-Year Retrospective Case Series [J].
Dorterler, Mustafa Erman .
EMERGENCY MEDICINE INTERNATIONAL, 2019, 2019
[3]   Initial clinical application of tissue pH neutralization after esophageal button battery removal in children [J].
Jatana, Kris R. ;
Barron, Christine L. ;
Jacobs, Ian N. .
LARYNGOSCOPE, 2019, 129 (08) :1772-1776
[4]   Button Battery Safety Industry and Academic Partnerships to Drive Change [J].
Jatana, Kris R. ;
Chao, Silas ;
Jacobs, Ian N. ;
Litovitz, Toby .
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA, 2019, 52 (01) :149-161
[5]   Basic Mechanism of Button Battery Ingestion Injuries and Novel Mitigation Strategies After Diagnosis and Removal [J].
Jatana, Kris R. ;
Rhoades, Keith ;
Milkovich, Scott ;
Jacobs, Ian N. .
LARYNGOSCOPE, 2017, 127 (06) :1276-1282
[6]   Pediatric button battery injuries: 2013 task force update [J].
Jatana, Kris R. ;
Litovitz, Toby ;
Reilly, James S. ;
Koltai, Peter J. ;
Rider, Gene ;
Jacobs, Ian N. .
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 2013, 77 (09) :1392-1399
[7]   Edible Oils Attenuate Button Battery-Induced Injury in Porcine Esophageal Segments [J].
Jia, Wenyuan ;
Zhang, Bin ;
Xu, Guanghui ;
Xie, Jiangang ;
Wei, Haidong ;
Shan, Niqi ;
Wang, Qianmei ;
Yin, Wen ;
Zhao, Wei .
FRONTIERS IN PEDIATRICS, 2020, 8
[8]   Serious complications after button battery ingestion in children [J].
Krom, Hilde ;
Visser, Margot ;
Hulst, Jessie M. ;
Wolters, Victorien M. ;
Van den Neucker, Anita M. ;
de Meij, Tim ;
van der Doef, Hubert P. J. ;
Norbruis, Obbe F. ;
Benninga, Marc A. ;
Smit, Margot J. M. ;
Kindermann, Angelika .
EUROPEAN JOURNAL OF PEDIATRICS, 2018, 177 (07) :1063-1070
[9]   Esophageal lesions following button-battery ingestion in children: Analysis of causes and proposals for preventive measures [J].
Lahmar, J. ;
Celerier, C. ;
Garabedian, E. N. ;
Couloigner, V. ;
Leboulanger, N. ;
Denoyelle, F. .
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES, 2018, 135 (02) :91-94
[10]   Foreign Body Ingestion in Children [J].
Lee, Ji Hyuk .
CLINICAL ENDOSCOPY, 2018, 51 (02) :129-136