Neuropeptide Y in neural crest-derived tumors: Effect on growth and vascularization

被引:16
|
作者
Kitlinska, Joanna [1 ]
机构
[1] Georgetown Univ, Med Ctr, Dept Physiol & Biophys, Washington, DC 20057 USA
关键词
neuropeptide Y; neural crest-derived tumors; neuroblastoma; Ewing's sarcoma family of tumors; pheochromocytoma; angiogenesis;
D O I
10.1016/j.canlet.2006.01.010
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Neuropeptide Y (NPY) is a sympathetic neurotransmitter recently found to be a potent growth and angiogenic factor. The peptide and its receptors are abundant in neural crest-derived tumors, such as sympathetic neuroblastomas and pheochromocytomas, as well as parasympathetic Ewing's sarcoma family of tumors. NPY regulates their growth directly, by an autocrine activation of tumor cell proliferation or apoptosis, and indirectly, by its angiogenic activity. The overall effect of the peptide on tumor growth depends on a balance between these processes and the type of receptors expressed in the tumor cells. Thus, NPY and its receptors may become targets for the treatment of neural tumors, directed against both tumor cell proliferation and angiogenesis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:293 / 302
页数:10
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