Synthesis, Characterization, and Antibacterial Activity of 7-Fluoro-2-oxo-2H-chromene-3-carboxylic Acid Ethyl Ester

被引：1

作者：

Rani, N. Latha ^{[1
]}

Prashanth, T. ^{[2
,3
]}

Sridhar, M. A. ^{[1
]}

Ranganatha, V. Lakshmi ^{[2
]}

Shaukath, A. K. ^{[2
]}

Lokanath, N. K. ^{[1
]}

机构：

[1] Univ Mysore, Dept Studies Phys, Mysore 570006, Karnataka, India

[2] Univ Mysore, Yuvarajas Coll Autonomous, Dept Chem, Mysore 570006, Karnataka, India

[3] Natl Inst Engn Autonomous, Dept Chem, Mysore, Karnataka, India

来源：

MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2015年 / 623卷 / 01期

关键词：

Bacillus cereus; coumarin; Escherichia coli; pseudomonas aeruginosa; salmonella typhimurium; staphylococcus aureus;

D O I：

10.1080/15421406.2015.1011453

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The title compound was synthesized by reacting 2-hydroxy-4-methoxy-benzaldehyde with diethyl malonate in the presence of catalyst piperidine. The compound was characterized by elemental analysis, FT-IR, H-1-NMR, and C-13-NMR. The structure was confirmed by single crystal X-ray diffraction technique. The compound crystallizes in the monoclinic crystal system, P2(1)/n space group with unit cell parameters a = 7.8824(7) angstrom, b = 13.5854(10) angstrom, c = 20.6072(16) angstrom, beta = 98.786(3)degrees, and Z = 8. The molecular and crystal structure of the title compound are stabilized by inter- and intramolecular interactions of the type C-H center dot center dot center dot O. This newly synthesized compound was screened for antibacterial activity with two Gram positive and three Gram negative bacteria.

引用

页码：265 / 274

页数：10

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