Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy

被引：164

作者：

Tan, NCK

Heron, SE

Scheffer, IE

Pelekanos, JT

McMahon, JM

Vears, DF

Mulley, JC

Berkovic, SF

机构：

[1] Univ Melbourne, Epilepsy Res Ctr, Austin Hlth, Heidelberg, Vic 3081, Australia

[2] Univ Melbourne, Dept Med, Parkville, Vic 3052, Australia

[3] Univ Adelaide, Womens & Childrens Hosp, Dept Med Genet, Adelaide, SA 5005, Australia

[4] Univ Adelaide, Dept Mol Biosci, Adelaide, SA 5005, Australia

来源：

NEUROLOGY | 2004年 / 63卷 / 06期

关键词：

D O I：

10.1212/01.WNL.0000137051.33486.C7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance.

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页码：1090 / 1092

页数：3

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