Cytotoxic diarylheptanoids from the Roots of Juglans mandshurica

被引：85

作者：

Lee, KS

Li, G

Kim, SH

Lee, CS

Woo, MH

Lee, SH

Jhang, YD

Son, JK ^{[1
]}

机构：

[1] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea

[2] Yeungnam Univ, Coll Sci, Dept Biochem, Kyongsan 712749, South Korea

[3] Catholic Univ Daegu, Coll Pharm, Gyongsan 712702, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 11期

关键词：

D O I：

10.1021/np0201063

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new (2) and three known diarylheptanoids (1, 3, and 4), along with one known sesquiterpenoid (5), were isolated from the roots of Juglans mandshurica, and their structures were elucidated on the basis of spectroscopic studies. Four of these compounds (2-5) exhibited moderate cytotoxicities against human colon carcinoma and human lung carcinoma cell lines with IC50's ranging from 2 to 25 mug/mL.

引用

页码：1707 / 1708

页数：2

共 18 条

[1] SYNTHETIC STUDIES OF SESQUITERPENES WITH A CIS-FUSED DECALIN SYSTEM .4. SYNTHESIS OF (+)-5-BETA-H-EUDESMA-3,11-DIENE, (-)-5-BETA-H-EUDESMANE-4-BETA,11-DIOL AND (+)-5-BETA-H-EUDESMANE-4-ALPHA,11-DIOL, AND STRUCTURE REVISION OF A NATURAL EUDESMANE-4,11-DIOL ISOLATED FROM PLUCHEA-ARGUTA [J].