Coumarin-based fluorescent probe for the detection of glutathione and nitroreductase

被引：8

作者：

Tian, Xue ^{[1
]}

Kumawat, Lokesh K. ^{[2
,3
]}

Bull, Steven D. ^{[1
]}

Elmes, Robert B. P. ^{[2
,3
,4
]}

Wu, Luling ^{[1
]}

James, Tony D. ^{[1
,5
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] Natl Univ Ireland, Maynooth Univ, Dept Chem, Maynooth, Kildare, Ireland

[3] Natl Univ Ireland, Maynooth Univ, Kathleen Lonsdale Inst Human Hlth Res, Maynooth, Kildare, Ireland

[4] Maynooth Univ, Synth & Solid State Pharmaceut Ctr, Maynooth, Kildare, Ireland

[5] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

来源：

TETRAHEDRON | 2021年 / 82卷

基金：

爱尔兰科学基金会; 英国工程与自然科学研究理事会;

关键词：

Fluorescent probe; Nitroreductase; Glutathione;

D O I：

10.1016/j.tet.2020.131890

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

With this research we set out to develop a coumarin-based novel fluorescent probe NTR-AHC for the detection of biological thiols and nitroreductase (NTR). Probe NTR-AHC was constructed by attaching the NTR trigger moiety (p-nitrobenzyl) and biothiol acceptor (maleic acid monoamide), to the core fluorophore AHC. In the presence of both glutathione (GSH) and NTR, probe NTR-AHC produced a >8-fold increase in fluorescence intensity at 463 nm. (C) 2020 Published by Elsevier Ltd.

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页数：5

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