Pulsatile ocular blood flow during pregnancy

被引:36
作者
Centofanti, M
Migliardi, R
Bonini, S
Manni, G
Bucci, MG
Pesavento, CB
Amin, CS
Harris, A
机构
[1] Indiana Univ, Sch Med, Dept Ophthalmol, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Dept Physiol & Biophys, Indianapolis, IN 46202 USA
[3] Univ Roma Tor Vergata, Ophthalmol Clin, Fondaz GB Bietti Oftalmol Onlus, Rome, Italy
关键词
POBF; ocular blood flow; estrogen; pregnancy;
D O I
10.1177/112067210201200404
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE, To study pulsatile ocular blood flow (POBF) throughout pregnancy. METHODS. We enrolled twenty-seven healthy women in the first trimester of gestation, only ten of which were followed through the second trimester, and fourteen non pregnant healthy women. In each subject we measured POBF with the POBF pneumotonometer (OBF Ltd. UK), IOP, blood pressure (BP) and heart rate (HR). An unpaired Student t-test was used to compare pregnant women with non-pregnant women, and a two-tailed paired Student t-test was used to compare the same women in the first and second trimester of pregnancy. p < 0.05 is considered statistically significant. RESULTS. Results are presented as means +/- SD. In the first trimester of pregnancy the age was 32 +/- 6, POBF 1516.4 +/- 382 ml/min, IOP 13 +/- 3 mmHg, BP 92 +/- 6 mmHg, and HR 86 +/- 14 beats/min. In the second trimester POBF was 1629.11 +/- 352.4 ml/min, intraocular pressure (IOP) 12 +/- 3 mmHg, BP 96 +/- 3 mmHg, and HR 93 +/- 10 beats/min. In the control group the age was 27 +/- 9, POBF 972.23 +/- 329.3 mllmin, BP 88 +/- 4.3 mmHg, and HR 80 +/- 14 beats/min. POBF increases during the first trimester (p = 0.00008). In the second trimester POBF was higher compared to the first trimester (p = 0.0008). Non significant differences were observed for the other parameters. CONCLUSIONS. The POBF increases throughout gestation. During pregnancy there is an increase in estrogen which induces endothelial-dependent vasodilatation in several tissues. The estrogen changes may influence POBF.
引用
收藏
页码:276 / 280
页数:5
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