Tuberculosis: A comprehensive study on its evolution, variants, causes and treatment related challenges

Tuberculosis, one of the most appalling disorders of the ancient times and still the major fatality affecting bacterial infection, is the condition principally concerned with the pulmonary complexities as well as sometimes damaging extra-pulmonary regions in the body also, demands proper medication and monitoring to be rectified effectively. In countries like India, the incremental prevalence of the resistant TB makes it obligatory to act rigorously in order to control the TB cases and adhere to the TB management programmes. Resistant tuberculosis represents the irrepressible state where the available TB drugs become insufficient for the treatment, worsening the lives of the sufferers. The situation is emerging in such a way that there would the time when the encountered totally-drug resistant cases become effectively high, emphasizing the necessity to develop drugs with improvised antagonistic capabilities to eradicate the existence of Mycobacterium. This review represents a thorough study of the dreadful existence of the pathogen providing all the required information for a better understanding of the disease and its resistance.