A short, chemoenzymatic route to chiral β-aryl-γ-amino acids using reductases from anaerobic bacteria

被引：25

作者：

Fryszkowska, Anna ^{[1
,2
]}

Fisher, Karl ^{[1
,3
]}

Gardiner, John M. ^{[1
,2
]}

Stephens, Gill M. ^{[1
,3
]}

机构：

[1] Univ Manchester, Manchester Interdisciplinary Bioctr, Manchester M1 7DN, Lancs, England

[2] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

[3] Univ Manchester, Sch Chem Engn & Analyt Sci, Manchester M60 1QD, Lancs, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

CARBON DOUBLE-BONDS; OLD YELLOW ENZYMES; ASYMMETRIC BIOREDUCTION; ENOATE REDUCTASES; CLOSTRIDIUM-SPOROGENES; ACETOBACTERIUM-WOODII; REDUCTION; (R)-(-)-BACLOFEN; HYDROGENATION; NITROALKENES;

D O I：

10.1039/b919526b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short chemoenzymatic synthesis of beta-aryl-gamma-aminobutyric acids has been developed, based on a highly enantioselective biocatalytic reduction of beta-aryl-beta-cyano-alpha, beta-unsaturated carboxylic acids.

引用

页码：533 / 535

页数：3

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