Characterization of ofloxacin-oxalic acid complex by PXRD, NMR, and THz spectroscopy

被引：26

作者：

Limwikrant, Waree ^{[1
]}

Higashi, Kenjirou ^{[1
]}

Yamamoto, Keiji ^{[1
]}

Moribe, Kunikazu ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2009年 / 382卷 / 1-2期

关键词：

Ofloxacin; Oxalic acid; Complex; Grinding; Terahertz time-domain spectroscopy; TERAHERTZ PULSED SPECTROSCOPY; PHARMACEUTICAL MATERIALS; CRYSTAL-STRUCTURE; TECHNOLOGY; HYDRATE; SPECTRA; DRUG;

D O I：

10.1016/j.ijpharm.2009.08.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel ofloxacin-oxalic acid complex was prepared by the cogrinding method. The obtained complex was characterized by powder X-ray diffraction (PXRD), infrared (IR), solid-state nuclear magnetic resonance (NMR), and terahertz (THz) spectroscopy. The PXRD measurement revealed that the ofloxacin-oxalic acid complex induced by cogrinding was formed at a molar ratio of 1:2. Weak interaction between two components, not a hydrogen bonding, was found by IR and solid-state NMR spectroscopy. The distinctive THz spectrum showed that the vibrational modes of the complex were different from those of the starting materials, suggesting that THz spectroscopy is an alternative tool to evaluate complex formation through weak interactions. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：50 / 55

页数：6

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