Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: Development of novel spiropiperidines

被引：12

作者：

Burgey, Christopher S. ^{[1
]}

Potteiger, Craig M. ^{[1
]}

Deng, James Z. ^{[1
]}

Mosser, Scott D. ^{[2
]}

Salvatore, Christopher A. ^{[2
]}

Yu, Sean ^{[3
]}

Roller, Shane ^{[3
]}

Kane, Stefanie A. ^{[2
]}

Vacca, Joseph P. ^{[1
]}

Williams, Theresa M. ^{[1
]}

机构：

[1] Merck Res Labs, Dept Med Chem, West Point, PA 19486 USA

[2] Merck Res Labs, Dept Pain & Migraine Res, West Point, PA 19486 USA

[3] Merck Res Labs, Dept Drug Metab, West Point, PA 19486 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 22期

关键词：

CGRP; CGRP receptor antagonists; Migraine; Calcitonin gene-related peptide; MIGRAINE; MK-0974; POTENT;

D O I：

10.1016/j.bmcl.2009.09.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：6368 / 6372

页数：5

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