The crystallization behavior of proline and its role in asymmetric organocatalysis

被引：42
作者：
Kellogg, Richard M. [1 ]
机构：
[1] Syncom BV, NL-9474 AT Groningen, Netherlands
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 04期
关键词：
asymmetric catalysis; chirality; phase diagrams; proline; solvent effects; ENANTIOMERIC EXCESS; AMPLIFICATION; CATALYSIS; RATIONALIZATION; ALDOL;
D O I：
10.1002/anie.200603028
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) What you have and what you get are not necessarily the same: for example, solid enantiomerically enriched proline provides solutions of constant ee, 99% in CHCl3 and 50% in DMSO. The Highlight discusses recent papers that give insight into the behavior of enantioenriched proline under heterogeneous conditions which may provide an explanation for the nonlinear effects sometimes observed. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：494 / 497
页数：4
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