The Roles of MicroRNA-141 in Human Cancers: From Diagnosis to Treatment

被引：96

作者：

Gao, Yanping ^{[1
]}

Feng, Bing ^{[1
]}

Han, Siqi ^{[1
]}

Zhang, Kai ^{[1
]}

Chen, Jing ^{[1
]}

Li, Chen ^{[1
]}

Wang, Rui ^{[1
]}

Chen, Longbang ^{[1
]}

机构：

[1] Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Oncol, Zhongshan East Rd 305, Nanjing 210002, Jiangsu, Peoples R China

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2016年 / 38卷 / 02期

基金：

中国国家自然科学基金;

关键词：

MiR-141; Epithelial-mesenchymal transition; Proliferation; Metastasis; Diagnosis; RENAL-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITIONS; HEPATOCYTE NUCLEAR FACTOR-3-BETA; ISOTHIOCYANATE-INDUCED APOPTOSIS; MODULATES CISPLATIN SENSITIVITY; NONCODING RNA HOTAIR; PROSTATE-CANCER; DOWN-REGULATION; GASTRIC-CANCER; TRANSCRIPTIONAL COACTIVATOR;

D O I：

10.1159/000438641

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer remains one of the most threatening causes of human health impairment, and the mechanisms underlying tumorigenesis have not been completely characterized. MicroRNAs (miRNAs) are a group of endogenous, small (18 similar to 25 nucleotides) non-coding RNAs which negatively regulate gene expressions by directly binding to the 3'-untranslated regions (3'UTRs) of the target messenger RNAs (mRNAs). Increasing evidence has demonstrated abnormal miRNA profiles and confirmed their involvement in tumor initiation and progression. As one important member of the miR-200 family, microRNA (miR)-141 is aberrantly expressed in many human malignant tumors, participating in various cellular processes including epithelial-mesenchymal transition (EMT), proliferation, migration, invasion, and drug resistance. In the present review, we briefly describe the mechanisms underlying miR-141-mediated tumorigenesis and the possible future of miR-141 as a potential diagnostic and prognostic parameter as well as therapeutic target in clinical applications. (C) 2016 The Author(s) Published by S. Karger AG, Basel

引用

页码：427 / 448

页数：22

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