Associated Strengthening Exercises to Undenatured Oral Type II Collagen (UC-II). A Randomized Study in Patients Affected by Knee Osteoarthritis

被引:6
作者
Costa, A. P. [1 ]
Teixeira, V. Cunha
Pereira, M.
Ferreira, P. Mota
Kuplich, P. A. [2 ]
Dohnert, M. B. [3 ]
da Silva Guths, J. F. [4 ]
Daitx, R. Boff [4 ]
机构
[1] Univ Luterana Brasil, Dept Physiotherapy, Torres, RS, Brazil
[2] Santa Luzia Hosp, Dept Orthoped & Traumatol, Capao Da Canoa, RS, Brazil
[3] Univ Gurupi UnirG, Res Teaching & Extens Lab Orthoped Trauma Physiot, Dept Physiotherapy, Gurupi, TO, Brazil
[4] Univ Luterana Brasil, Dept Physiotherapy, Torres, RS, Brazil
来源
MLTJ-MUSCLES LIGAMENTS AND TENDONS JOURNAL | 2020年 / 10卷 / 03期
关键词
Knee; osteoarthritis; Circuit-Based Exercise; nutraceuticals; collagen type II; muscle strength;
D O I
10.32098/mltj.03.2020.18
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Background. Osteoarthritis (OA) is a chronic joint disease characterized by progressive degeneration of articular cartilage. It affects 20-25% of the population older than 45 years. The objective was to evaluate the effect of combining muscle strengthening exercises with the administration of oral type II undenatured collagen formulation (UC-II) in people with knee OA. Methods. A double-blind, placebo-controlled, randomized controlled trial with 60 patients with knee OA, randomly divided into the following groups: UC-II and physiotherapy group (CPG), placebo UC-II and physiotherapy group (PCPG), and physiotherapy group (PG). For groups using an oral type II undenatured collagen formulation, UC-II, 40 mg/day UC-II was administered for 90 days. Muscle strengthening exercises were associated with neuromuscular electrical stimulation (NMES), being performed three times a week for 30 days. At 30 and 90 days and six months after the intervention, the following were evaluated: pain, quality of life, functional capacity, muscle strength, and joint mobility. Results. Pain improved in all intervention groups, with no difference between groups. Quadriceps muscle strength increased in the CPG (p<0.005) and PG (p<0.05), the same being observed for active and passive knee flexion mobility (p<0.05). All groups decreased the TUG test execution time after 30 days (p<0.005 for the CPG and PG, and p<0.05 for the PCPG), but only the CPG and PG maintained the scores at 90-day and six-month assessments (p<0.005). Regarding the 6MWT, only the CPG increased the distance covered in all assessments (p<0.005). The PG traveled a greater distance than the PCPG at the 90-day assessment (p<0.05). The WOMAC score decreased significantly in all intervention groups. The Lequesne score decreased in all groups; however, the CPG and PG showed lower values at 30 days (p<0.005). Conclusions. Muscle strengthening exercises improved pain, mobility, strength, and function in knee OA patients. The association of UC-II seems to have accentuated the effect of exercise on this clinical improvement, especially in the long term.
引用
收藏
页码:481 / 492
页数:12
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