Sialidases: Structures, biological significance and therapeutic potential

被引：200
作者：
Taylor, G
机构：
[1] School of Biology and Biochemistry, University of Bath
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1996年 / 6卷 / 06期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S0959-440X(96)80014-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structure-based design of a potent inhibitor of the influenza-virus neuraminidase (sialidase) is one of the outstanding successes of rational drug design. Recent clinical trials of the drug have stimulated many companies to seek a share of the potentially huge flu market. Sialidases, however, are involved in the pathogenesis of a whole range of other diseases, so perhaps the knowledge and expertise gained from the influenza story can be used in the design of other drugs, given that they all share certain structural features.
引用
收藏
页码：830 / 837
页数：8
相关论文
共 54 条
[1]  
ANG HB, 1996, INFECT IMMUN, V64, P37
[2]   TOWARDS THE SYNTHESIS OF SIALIC ACID-BASED SALMONELLA-TYPHIMURIUM SIALIDASE INHIBITORS [J].
ANGUS, DI ;
VONITZSTEIN, M .
CARBOHYDRATE RESEARCH, 1995, 274 :279-283
[3]   SYNTHESIS OF 6-CARBON, 7-CARBON AND 8-CARBON SUGAR ANALOGS OF POTENT ANTIINFLUENZA 2,3-DIDEHYDRO-2,3-DIDEOXY-N-ACETYLNEURAMINIC ACID-DERIVATIVES [J].
BAMFORD, MJ ;
PICHEL, JC ;
HUSMAN, W ;
PATEL, B ;
STORER, R ;
WEIR, NG .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1995, (09) :1181-1187
[4]   Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en [J].
Blick, TJ ;
Tiong, T ;
Sahasrabudhe, A ;
Varghese, JN ;
Colman, PM ;
Hart, GJ ;
Bethell, RC ;
McKimmBreschkin, JL .
VIROLOGY, 1995, 214 (02) :475-484
[5]   A SINGLE AMINO-ACID CHANGE ENHANCES THE FUSION PROMOTION ACTIVITY OF HUMAN PARAINFLUENZA VIRUS TYPE-1 HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN [J].
BOUSSE, T ;
TAKIMOTO, T ;
PORTNER, A .
VIROLOGY, 1995, 209 (02) :654-657
[6]   FLOW CYTOFLUOROMETRIC ANALYSIS OF YOUNG AND SENESCENT HUMAN ERYTHROCYTES PROBED WITH LECTINS - EVIDENCE THAT SIALIC ACIDS CONTROL THEIR LIFE-SPAN [J].
BRATOSIN, D ;
MAZURIER, J ;
DEBRAY, H ;
LECOCQ, M ;
BOILLY, B ;
ALONSO, C ;
MOISEI, M ;
MOTAS, C ;
MONTREUIL, J .
GLYCOCONJUGATE JOURNAL, 1995, 12 (03) :258-267
[7]  
CAMARA M, 1994, INFECT IMMUN, V62, P3688
[8]   TRYPANOSOMA-CRUZI TRANS-SIALIDASE - ENHANCEMENT OF VIRULENCE IN A MURINE MODEL OF CHAGAS-DISEASE [J].
CHUENKOVA, M ;
PEREIRA, MEA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (05) :1693-1703
[9]   Plasmodium falciparum lacks sialidase and trans-sialidase activity [J].
Clough, B ;
Atilola, FA ;
Healy, N ;
Pereira, MEA ;
Bethell, RC ;
Penn, CR ;
Pasvol, G .
PARASITOLOGY, 1996, 112 :443-449
[10]   SEQUENCE AND STRUCTURE ALIGNMENT OF PARAMYXOVIRUS HEMAGGLUTININ-NEURAMINIDASE WITH INFLUENZA-VIRUS NEURAMINIDASE [J].
COLMAN, PM ;
HOYNE, PA ;
LAWRENCE, MC .
JOURNAL OF VIROLOGY, 1993, 67 (06) :2972-2980
123456