The precursors of memory: models and controversies

被引：146

作者：

Ahmed, Rafi ^{[1
]}

Bevan, Michael J. ^{[2
]}

Reiner, Steven L. ^{[3
,4
]}

Fearon, Douglas T. ^{[5
]}

机构：

[1] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[2] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA

[3] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[5] Univ Cambridge, Dept Med, Med Res Council Ctr, Wellcome Trust Immunol Unit, Cambridge CB2 2QH, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 09期

关键词：

CD8; T-CELLS; IL-7; RECEPTOR-ALPHA; VIRAL-INFECTION; CUTTING EDGE; LINEAGE RELATIONSHIP; NONLYMPHOID TISSUES; IMMUNE-RESPONSES; FATE DECISIONS; IN-VIVO; EFFECTOR;

D O I：

10.1038/nri2619

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The adaptive immune system has evolved a unique capacity to remember a pathogen through the generation of memory T cells, which rapidly protect the host in the event of reinfection. How memory T cells develop and the relationship between effector and memory T cells has been actively debated in the literature for many years and several models have been proposed to explain the divergent developmental fates of T cell progeny. Here, Nature Reviews Immunology asks four leading researchers in the field to provide their thoughts and opinions on the ontogeny of memory T cells and its implications for vaccine design.

引用

页码：662 / 668

页数：7

共 57 条

[21] Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor [J].