The precursors of memory: models and controversies

被引：146
作者：
Ahmed, Rafi [1 ]
Bevan, Michael J. [2 ]
Reiner, Steven L. [3 ,4 ]
Fearon, Douglas T. [5 ]
机构：
[1] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA
[2] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA
[3] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Med, Philadelphia, PA 19104 USA
[5] Univ Cambridge, Dept Med, Med Res Council Ctr, Wellcome Trust Immunol Unit, Cambridge CB2 2QH, England
来源：
NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 09期
关键词：
CD8; T-CELLS; IL-7; RECEPTOR-ALPHA; VIRAL-INFECTION; CUTTING EDGE; LINEAGE RELATIONSHIP; NONLYMPHOID TISSUES; IMMUNE-RESPONSES; FATE DECISIONS; IN-VIVO; EFFECTOR;
D O I：
10.1038/nri2619
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The adaptive immune system has evolved a unique capacity to remember a pathogen through the generation of memory T cells, which rapidly protect the host in the event of reinfection. How memory T cells develop and the relationship between effector and memory T cells has been actively debated in the literature for many years and several models have been proposed to explain the divergent developmental fates of T cell progeny. Here, Nature Reviews Immunology asks four leading researchers in the field to provide their thoughts and opinions on the ontogeny of memory T cells and its implications for vaccine design.
引用
收藏
页码：662 / 668
页数：7
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