Gut Microbial Signatures Associated with Peanut Allergy in a BALB/c Mouse Model

被引：23

作者：

Gu, Shimin ^{[1
]}

Xie, Qiang ^{[1
]}

Chen, Chen ^{[1
]}

Liu, Chenglong ^{[1
]}

Xue, Wentong ^{[1
]}

机构：

[1] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China

来源：

FOODS | 2022年 / 11卷 / 10期

关键词：

peanut; allergy; gut microbiota; 16S rRNA sequencing; predicted functions; FOOD ALLERGY; BACTERIAL COMMUNITY; ORAL IMMUNOTHERAPY; INDUCTION; CLONING; MILK; MICE;

D O I：

10.3390/foods11101395

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Multiple studies have uncovered the pivotal role of gut microbiota in the development of food allergy. However, the effects of gut microbiota on peanut allergy are still unclear. Here, we characterized the gut microbiota composition of peanut-allergic mice by 16S rRNA sequencing and analyzed the correlation between allergic indicators and gut microbiota composition. Outcomes showed that the gut microbiota composition was reshaped in peanut-allergic mice, with Acidobacteriota, Lachnospiraceae, Rikenellaceae, Alistipes, Lachnospiraceae NK4A136_group significantly down-regulated and Muribaculaceae up-regulated. All of them were significantly correlated with the serum peanut-specific antibodies. These results suggested that these six bacterial OTUs might be the gut microbial signatures associated with peanut allergy.

引用

页数：14

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