Expression and activity of potassium ion channels in human prostate cancer

被引：123
作者：
Abdul, M [1 ]
Hoosein, N [1 ]
机构：
[1] Rumbaugh Goodwin Inst Canc Res, Plantation, FL 33313 USA
来源：
CANCER LETTERS | 2002年 / 186卷 / 01期
关键词：
prostate cancer; voltage-gated; potassium channel; proliferation; amiodarone;
D O I：
10.1016/S0304-3835(02)00348-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Four normal and 79 human prostate cancer (Pca) specimens were examined, by immunohistochemistry, for expression of voltage-gated potassium ion channels. Strong immunostaining (for Kv1.3) was observed in the normal and 47% (37/79) of Pea specimens. Twenty-nine percent (23/79) Pca specimens showed moderate and 24% (19/79) displayed low staining. Three potassium channel-openers at a concentration of 10 mug/mL, minoxidil (47.8 muM), 1-Ethyl-2-benzimidazolinone (EBIO) (61.7 muM) and diazoxide (43.3 muM), increased growth of PC3 cells by 30-50%. Potassium channel-blockers, dequalinium, amiodarone and glibenclamide, caused a dose-dependent, growth inhibition of four human Pca cell lines. Apoptosis occurred within 4 h of treatment of PC3 cells with dequalinium (0.5 mug/mL, 0.9 muM), amiodarone (5 mug/mL, 7.3 muM) or glibenclamide (50 mug/mL, 0.1 mM). (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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页码：99 / 105
页数：7
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