Diastereoselective synthesis of (5R,7R)- and (5R,7S)-5,7-dimethyl-6,7-dihydro-5H-dibenz[c,e]azepines

被引：0

作者：

Saudan, LA ^{[1
]}

Bernardinelli, G ^{[1
]}

Kündig, EP ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

SYNLETT | 2000年 / 04期

关键词：

diastereoselective imine alkylation; chiral azepine; Stille biaryl coupling; palladium; enantioselective lithiation;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from (R)-1-(2-methoxyphenyl)ethylamine, the title compounds were synthesized, Key steps are a diastereoselective imine alkylation and a Pd-catalyzed biaryl coupling. The benzylic stereogenic centers of the (5R,7R)-azepine induce a strong bias for the atropisomeric conformer having aS axial chirality and pseudo equatorial Me groups.

引用

页码：483 / 486

页数：4

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