Methotrexate induced seizures associated with acute reversible magnetic resonance imaging (MRI) changes in a patient with acute lymphoblastic leukemia

被引：11
作者：
Rao, RD [1 ]
Swanson, JW [1 ]
Dejesus, RS [1 ]
Hunt, CH [1 ]
Tefferi, A [1 ]
机构：
[1] Mayo Clin & Mayo Fdn, Div Hematol & Internal Med, Rochester, MN 55905 USA
来源：
LEUKEMIA & LYMPHOMA | 2002年 / 43卷 / 06期
关键词：
methotrexate; neurotoxicity; seizure; acute lymphocytic leukemia; MRI;
D O I：
10.1080/10428190290026402
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A 27-year-old woman with acute lymphoblastic leukemia (ALL) had an episode of generalized tonic clonic seizure after therapy with intrathecal and intravenous methotrexate (MTX). Magnetic resonance imaging (MRI) of her head showed meningeal, cortical and subcortical enhancement that was new when compared to a study done prior to therapy. Subsequent imaging 10 days later showed partial resolution of these findings. The association of seizures and MTX in ALL and the corresponding MRI changes are discussed.
引用
收藏
页码：1333 / 1336
页数：4
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