The role of beta(2)-glycoprotein I in the antiphospholipid syndrome

被引：8
作者：
Krilis, SA
Sheng, YH
Kandiah, DA
机构：
来源：
LUPUS | 1996年 / 5卷 / 02期
关键词：
antiphospholipid syndrome; antiphospholipid antibodies; beta(2)-glycoprotein I;
D O I：
10.1177/096120339600500211
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Antiphospholipid antibodies were originally thought to bind negatively-charged (aniomic) phospholipids. Current evidence suggests that the target antigen is considerably more complex and includes beta(2)-glycoprotein I, a phospholipid-binding plasma protein. Our understanding of the pathophysiology of the antiphospholipid syndrome has increased exponentially with a number of studies into the interactions of antiphospholipid antibodies and beta(2)-glycoprotein I.
引用
收藏
页码：150 / 152
页数：3
相关论文
共 16 条
[1]   MEASUREMENT OF ANTIPHOSPHOLIPID ANTIBODIES BY ELISA USING BETA-2-GLYCOPROTEIN-I AS AN ANTIGEN [J].
ARVIEUX, J ;
ROUSSEL, B ;
JACOB, MC ;
COLOMB, MG .
JOURNAL OF IMMUNOLOGICAL METHODS, 1991, 143 (02) :223-229
[2]   ANTICARDIOLIPIN ANTIBODIES (ACA) DIRECTED NOT TO CARDIOLIPIN BUT TO A PLASMA-PROTEIN COFACTOR [J].
GALLI, M ;
COMFURIUS, P ;
MAASSEN, C ;
HEMKER, HC ;
DEBAETS, MH ;
VANBREDAVRIESMAN, PJC ;
BARBUI, T ;
ZWAAL, RFA ;
BEVERS, EM .
LANCET, 1990, 335 (8705) :1544-1547
[3]  
HUNT J, 1994, J IMMUNOL, V152, P653
[4]   A PHOSPHOLIPID-BETA-2-GLYCOPROTEIN-I COMPLEX IS AN ANTIGEN FOR ANTICARDIOLIPIN ANTIBODIES OCCURRING IN AUTOIMMUNE-DISEASE BUT NOT WITH INFECTION [J].
HUNT, JE ;
MCNEIL, HP ;
MORGAN, GJ ;
CRAMERI, RM ;
KRILIS, SA .
LUPUS, 1992, 1 (02) :75-81
[5]   IDENTIFICATION OF A REGION OF BETA-2-GLYCOPROTEIN-I CRITICAL FOR LIPID-BINDING AND ANTICARDIOLIPIN ANTIBODY COFACTOR ACTIVITY [J].
HUNT, JE ;
SIMPSON, RJ ;
KRILIS, SA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (06) :2141-2145
[6]   BETA2-GLYCOPROTEIN-I [J].
KANDIAH, DA ;
KRILIS, SA .
LUPUS, 1994, 3 (04) :207-212
[7]   ANTIPHOSPHOLIPID ANTIBODIES - ANTICARDIOLIPIN AND THE LUPUS ANTICOAGULANT IN SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE) AND IN NON-SLE DISORDERS - PREVALENCE AND CLINICAL-SIGNIFICANCE [J].
LOVE, PE ;
SANTORO, SA .
ANNALS OF INTERNAL MEDICINE, 1990, 112 (09) :682-698
[8]   ANTICARDIOLIPIN ANTIBODIES RECOGNIZE BETA(2)-GLYCOPROTEIN-I STRUCTURE ALTERED BY INTERACTING WITH AN OXYGEN MODIFIED SOLID-PHASE SURFACE [J].
MATSUURA, E ;
IGARASHI, Y ;
YASUDA, T ;
TRIPLETT, DA ;
KOIKE, T .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (02) :457-462
[9]  
MCNEIL HP, 1991, ADV IMMUNOL, V49, P193
[10]   ANTIPHOSPHOLIPID ANTIBODIES ARE DIRECTED AGAINST A COMPLEX ANTIGEN THAT INCLUDES A LIPID-BINDING INHIBITOR OF COAGULATION - BETA-2-GLYCOPROTEIN-I (APOLIPOPROTEIN-H) [J].
MCNEIL, HP ;
SIMPSON, RJ ;
CHESTERMAN, CN ;
KRILIS, SA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (11) :4120-4124
12