The role of beta(2)-glycoprotein I in the antiphospholipid syndrome

被引：8
|
作者：
Krilis, SA
Sheng, YH
Kandiah, DA
机构：
来源：
LUPUS | 1996年 / 5卷 / 02期
关键词：
antiphospholipid syndrome; antiphospholipid antibodies; beta(2)-glycoprotein I;
D O I：
10.1177/096120339600500211
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Antiphospholipid antibodies were originally thought to bind negatively-charged (aniomic) phospholipids. Current evidence suggests that the target antigen is considerably more complex and includes beta(2)-glycoprotein I, a phospholipid-binding plasma protein. Our understanding of the pathophysiology of the antiphospholipid syndrome has increased exponentially with a number of studies into the interactions of antiphospholipid antibodies and beta(2)-glycoprotein I.
引用
收藏
页码：150 / 152
页数：3
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