Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases

被引：50

作者：

Babiloni, Claudio ^{[1
,2
]}

Del Percio, Claudio ^{[3
]}

Lizio, Roberta ^{[1
,2
]}

Noce, Giuseppe ^{[3
]}

Lopez, Susanna ^{[1
]}

Soricelli, Andrea ^{[3
,4
]}

Ferri, Raffaele ^{[5
]}

Pascarelli, Maria Teresa ^{[5
]}

Catania, Valentina ^{[5
]}

Nobili, Flavio ^{[6
,7
]}

Arnaldi, Dario ^{[6
,7
]}

Fama, Francesco ^{[6
,7
]}

Orzi, Francesco ^{[8
]}

Buttinelli, Carla ^{[8
]}

Giubilei, Franco ^{[8
]}

Bonanni, Laura ^{[9
,10
]}

Franciotti, Raffaella ^{[9
,10
]}

Onofrj, Marco ^{[9
,10
]}

Stirpe, Paola ^{[2
]}

Fuhr, Peter ^{[11
]}

Gschwandtner, Ute ^{[11
]}

Ransmayr, Gerhard ^{[12
]}

Garn, Heinrich ^{[13
]}

Fraioli, Lucia ^{[14
]}

Pievanim, Michela ^{[15
]}

D'Antonio, Fabrizia ^{[16
]}

De Lena, Carlo ^{[16
]}

Guntekin, Bahar ^{[17
]}

Hanoglu, Lutfu ^{[18
]}

Basar, Erol ^{[19
,20
]}

Yener, Gorsev ^{[19
,20
]}

Emek-Savas, Derya Durusu ^{[19
,21
]}

Triggiani, Antonio Ivano ^{[22
]}

Taylor, John Paul ^{[23
]}

De Pandis, Maria Francesca ^{[14
]}

Vacca, Laura ^{[24
]}

Frisoni, Giovanni B. ^{[15
,25
,26
,27
]}

Stocchi, Fabrizio ^{[2
]}

机构：

[1] Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Ple A Moro 5, I-00185 Rome, Italy

[2] IRCCS San Raffaele Pisana Roma & Cassino, Inst Res & Med Care, Rome, Italy

[3] IRCCS SDN, Dept Integrated Imaging, Naples, Italy

[4] Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy

[5] IRCCS Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy

[6] Univ Genoa, Dept Neurosci DiNOGMI, Clin Neurol, Genoa, Italy

[7] IRCCS AOU S Martino IST, Genoa, Italy

[8] Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy

[9] Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy

[10] Univ G dAnnunzio, CESI, Chieti, Italy

[11] Univ Spital Basel, Abt Neurophysiol, Petersgraben 4, CH-4031 Basel, Switzerland

[12] Johannes Kepler Univ Linz, Kepler Univ Hosp, Fac Med, Dept Neurol 2, Med Campus 3,Krankenhausstr 9, A-4020 Linz, Austria

[13] AIT Austrian Inst Technol GmbH, Vienna, Austria

[14] Hosp San Raffaele Cassino, Cassino, Italy

[15] IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy

[16] Univ Rome, Dept Neurol & Psychiat, Rome, Italy

[17] Istanbul Medipol Univ, Istanbul, Turkey

[18] Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey

[19] Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey

[20] Dokuz Eylul Univ, Med Sch, Dept Neurol, Izmir, Turkey

[21] Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey

[22] Univ Foggia, Dept Clin & Expt Med, Foggia, Italy

[23] Newcastle Univ, Inst Neurosci, Newcastle, England

[24] CCPP Milano SpA, Milan, Italy

[25] Univ Hosp Geneva, Memory Clin, Geneva, Switzerland

[26] Univ Hosp Geneva, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland

[27] Univ Geneva, Geneva, Switzerland

来源：

CLINICAL NEUROPHYSIOLOGY | 2018年 / 129卷 / 04期

关键词：

Functional brain connectivity; Resting state EEG rhythms; Mild cognitive impairment due to; Alzheimer's disease (ADMCI); Parkinson's disease (PDMCI); LEWY BODIES; EEG COHERENCE; QUANTITATIVE EEG; DIAGNOSTIC-CRITERIA; NEURAL SYNCHRONIZATION; MEMORY PERFORMANCE; BRAIN RHYTHMS; PHARMACO-EEG; DEMENTIA; OSCILLATIONS;

D O I：

10.1016/j.clinph.2018.01.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70-0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

引用

页码：766 / 782

页数：17

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