Molecular mechanisms of node of Ranvier formation

被引:105
作者
Susuki, Keiichiro [1 ]
Rasband, Matthew N. [1 ]
机构
[1] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA
关键词
D O I
10.1016/j.ceb.2008.09.007
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Action potential propagation along myelinated nerve fibers requires high-density protein complexes that include voltage-gated Na+ channels at the nodes of Ranvier. Several complementary mechanisms may be involved in node assembly including: (1) interaction of nodal cell adhesion molecules with the extracellular matrix; (2) restriction of membrane protein mobility by paranodal junctions; and (3) stabilization of ion channel clusters by axonal cytoskeletal scaffolds. In the peripheral nervous system, a secreted glial protein at the nodal extracellular matrix interacts with axonal cell adhesion molecules to initiate node formation. In the central nervous system, both glial soluble factors and paranodal axoglial junctions may function in a complementary manner to contribute to node formation.
引用
收藏
页码:616 / 623
页数:8
相关论文
共 44 条
[1]   Differential expression and functions of neuronal and glial neurofascin isoforms and splice variants during PNS development [J].
Basak, Sayantam ;
Raju, Karthik ;
Babiarz, Joanne ;
Kane-Goldsmith, Noriko ;
Koticha, Darshan ;
Grumet, Martin .
DEVELOPMENTAL BIOLOGY, 2007, 311 (02) :408-422
[2]   Axon-glia interactions and the domain organization of myelinated axons requires Neurexin IV/Caspr/Paranodin [J].
Bhat, MA ;
Rios, JC ;
Lu, Y ;
Garcia-Fresco, GP ;
Ching, W ;
St Martin, M ;
Li, JJ ;
Einheber, S ;
Chesler, M ;
Rosenbluth, J ;
Salzer, JL ;
Bellen, HJ .
NEURON, 2001, 30 (02) :369-383
[3]   Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve [J].
Boyle, MET ;
Berglund, EO ;
Murai, KK ;
Weber, L ;
Peles, E ;
Ranscht, B .
NEURON, 2001, 30 (02) :385-397
[4]   Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory [J].
Brakebusch, C ;
Seidenbecher, CI ;
Asztely, F ;
Rauch, U ;
Matthies, H ;
Meyer, H ;
Krug, M ;
Böckers, TM ;
Zhou, XH ;
Kreutz, MR ;
Montag, D ;
Gundelfinger, ED ;
Fässler, R .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (21) :7417-7427
[5]  
Custer AW, 2003, J NEUROSCI, V23, P10032
[6]   Nodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanisms [J].
Dzhashiashvili, Yulia ;
Zhang, Yanqing ;
Galinska, Jolanta ;
Lam, Isabel ;
Grumet, Martin ;
Salzer, James L. .
JOURNAL OF CELL BIOLOGY, 2007, 177 (05) :857-870
[7]   Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier [J].
Eshed, Y ;
Feinberg, K ;
Poliak, S ;
Sabanay, H ;
Sarig-Nadir, O ;
Spiegel, I ;
Bermingham, JR ;
Peles, E .
NEURON, 2005, 47 (02) :215-229
[8]   Secreted gliomedin is a perinodal matrix component of peripheral nerves [J].
Eshed, Yael ;
Feinberg, Konstantin ;
Carey, David J. ;
Peles, Elior .
JOURNAL OF CELL BIOLOGY, 2007, 177 (03) :551-562
[9]   Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin [J].
Garver, TD ;
Ren, Q ;
Tuvia, S ;
Bennett, V .
JOURNAL OF CELL BIOLOGY, 1997, 137 (03) :703-714
[10]   Neurofascin assembles a specialized extracellular matrix at the axon initial segment [J].
Hedstrom, Kristian L. ;
Xu, Xiaorong ;
Ogawa, Yasuhiro ;
Frischknecht, Renato ;
Seidenbecher, Constanze I. ;
Shrager, Peter ;
Rasband, Matthew N. .
JOURNAL OF CELL BIOLOGY, 2007, 178 (05) :875-886