Model Predictive Control of Glucose Feeding for Fed-batch Candida utilis Biomass Production

被引：0
|
作者：
Guo Qingqiang [1 ,2 ]
Liu Guoli [1 ,3 ]
Dong Nannan [1 ,4 ]
Li Qiqiang [2 ]
Lin Jianqun [1 ]
Lin Jianqiang [1 ]
机构：
[1] Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China
[2] Shandong Univ, Sch Control Sci & Engn, Jinan 250061, Peoples R China
[3] Liaoning Acad Agr Sci, Res Ctr Microbial Engn, Shenyang 110161, Peoples R China
[4] Tsingtao Brewery Jinan Co Ltd, Jinan 250104, Peoples R China
来源：
RESEARCH JOURNAL OF BIOTECHNOLOGY | 2013年 / 8卷 / 07期
关键词：
Fermentation; model predictive control; mathematical model; on-line monitoring; Candida utilis; LACTIC-ACID; FERMENTATION; OPTIMIZATION; CELLS;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In this work model predictive control (MPC) is used for control of glucose feeding rate of fed-batch culture for production of Candida utilis cell mass. A two layer hierarchical control system with the upper level for supervision and lower level for conventional control is designed which realizes automatic control, storage and refresh of kinetic model, data collection and on-line monitoring, data analysis and processing. The model stored in supervision computer is refreshed using genetic algorithm (GA) when the predictive error is over the limit. The results show that this method can control glucose concentration well and increase cell mass production effectively.
引用
收藏
页码：3 / 7
页数：5
相关论文
共 50 条
  • [31] Growth and carotenoid production of Phaffia Rhodozyma in fed-batch cultures with different feeding methods
    K.P. Ho
    C.Y. Tam
    B. Zhou
    Biotechnology Letters, 1999, 21 : 175 - 178
  • [32] Model-based control of titer and glycosylation in fed-batch mAb production: Modeling and control system development
    Luo, Yu
    Kurian, Varghese
    Song, Liqing
    Wells, Evan A.
    Robinson, Anne Skaja
    Ogunnaike, Babatunde A.
    AICHE JOURNAL, 2023, 69 (04)
  • [33] Growth and carotenoid production of Phaffia rhodozyma in fed-batch cultures with different feeding methods
    Ho, KP
    Tam, CY
    Zhou, B
    BIOTECHNOLOGY LETTERS, 1999, 21 (02) : 175 - 178
  • [34] Accelerated yoghurt production by fed-batch prefermentation
    Otten, J
    Verheij, CP
    Zoet, FD
    vanderLinden, HJLJ
    NETHERLANDS MILK AND DAIRY JOURNAL, 1996, 50 (01): : 19 - 34
  • [35] Application of model-predictive control based on artificial neural networks to optimize the fed-batch process for riboflavin production
    Kovárová-Kovar, K
    Gehlen, S
    Kunze, A
    Keller, T
    von Däniken, R
    Kolb, M
    van Loon, APGM
    JOURNAL OF BIOTECHNOLOGY, 2000, 79 (01) : 39 - 52
  • [36] Novel pH control strategy for glutathione overproduction in batch cultivation of Candida utilis
    Liang, Guobin
    Wang, Bin
    Xie, Jianghui
    Mo, Yiwei
    AFRICAN JOURNAL OF BIOTECHNOLOGY, 2009, 8 (22): : 6337 - 6345
  • [37] Real-time optimization and control for polyhydroxybutyrate fed-batch production at pilot plant scale
    Ochoa, Silvia
    Garcia, Cesar
    Alcaraz, Wilman
    JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2020, 95 (12) : 3221 - 3231
  • [38] Batch to Batch Iterative Learning Control of a Fed-Batch Fermentation Process
    Zhang, Jie
    Xiong, Zhihua
    Guillaume, Delautre
    Lamande, Alexandre
    MECHANICAL ENGINEERING AND TECHNOLOGY, 2012, 125 : 253 - +
  • [39] Fed-batch polyhydroxybutyrate production byParaburkholderia saccharifrom a ternary mixture of glucose, xylose and arabinose
    Li, Mengxing
    Wilkins, Mark R.
    BIOPROCESS AND BIOSYSTEMS ENGINEERING, 2021, 44 (01) : 185 - 193
  • [40] A straightforward logistic method for feeding a fed-batch baker's yeast culture
    Borowiak, Daniel
    Miskiewicz, Tadeusz
    Miszczak, Witold
    Cibis, Edmund
    Krzywonos, Malgorzata
    BIOCHEMICAL ENGINEERING JOURNAL, 2012, 60 : 36 - 43
12345