Anti-inflammatory potential of ellagic acid, gallic acid and punicalagin A&B isolated from Punica granatum

被引:316
作者
BenSaad, Lamees A. [1 ]
Kim, Kah Hwi [1 ]
Quah, Chin Chew [1 ]
Kim, Wee Ric [3 ]
Shahimi, Mustafa [2 ]
机构
[1] Malaysia Inst Med Res, Dept Physiol, Fac Med, Kuala Lumpur 50603, Malaysia
[2] Univ Coll Lincoln, Petaling Jaya 47301, Malaysia
[3] Malaysia Inst Med Res, Kuala Lumpur 50603, Malaysia
来源
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2017年 / 17卷
关键词
Inflammation; Punica granatum; Cytotoxicity; Cytokines; Ellagic acid; Gallic acid; Punicalagin; NITRIC-OXIDE; PROSTAGLANDIN E-2; POMEGRANATE; L; LIPOPOLYSACCHARIDE; INFLAMMATION; ANTIOXIDANT; EXTRACT; MACROPHAGES; ACTIVATION;
D O I
10.1186/s12906-017-1555-0
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Background: Punica granatum (pomegranate), an edible fruit originating in the Middle East, has been used as a traditional medicine for treatment of pain and inflammatory conditions such as peptic ulcer. The numerous risks associated with nonsteroidal anti-inflammatory drugs (NSAIDs) for treatment of pain and inflammation give rise to using medicinal herbs as alternative therapies. This study aimed to evaluate the anti-inflammatory effect of isolated compounds from the ethyl acetate (EtOAc) fraction of P. granatum by determination of their inhibitory effects on lipopolysaccharide (LPS), stimulated nitric oxide (NO), prostaglandin E2 (PGE-2), interleukin-6 (IL-6) and cyclooxxgenase-2 (COX-2) release from RAW264.7 cells. Methods: The compounds ellagic acid, gallic acid and punicalagin A&B were isolated from EtOAc by high performance liquid chromatography (HPLC) and further identified by mass spectrometry (MS). The inhibitory effect of ellagic acid, gallic acid and punicalagin A&B were evaluated on the production of LPS-induced NO by Griess reagent, PGE-2 and IL-6 by immunoassay kit and prostaglandin E2 competitive ELISA kit, and COX-2 by Western blotting. Results: Ellagic acid, gallic acid and punicalagin A&B potentially inhibited LPS-induced NO, PGE-2 and IL-6 production. Conclusion: The results indicate that ellagic acid, gallic acid and punicalagin may be the compounds responsible for the anti-inflammatory potential of P. granatum.
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页数:10
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