mTORC inhibitor Sirolimus deprograms monocytes in "cytokine storm" in SARS-CoV2 secondary hemophagocytic lymphohistiocytosis- like syndrome

被引：7

作者：

Karsulovic, Claudio ^{[1
,2
,3
]}

Lopez, Mercedes ^{[2
,4
]}

Tempio, Fabian ^{[2
,4
]}

Guerrero, Julia ^{[3
,5
]}

Goecke, Annelise ^{[1
,3
]}

机构：

[1] Univ Chile, Hosp Clin, Dept Med Interna, Secc Reumatol, Santiago, Chile

[2] Univ Chile, Fac Med, Inst Ciencias Biomed, Lab Regulac & Inmunol Canc,Programa Disciplinario, Santiago, Chile

[3] Univ Chile, Fac Med, Inst Ciencias Biomed, Lab Inmunomodulac Neuroendocrina,Programa Fisiol, Santiago, Chile

[4] Univ Chile, Fac Med, Inst Milenio Inmunol & Inmunoterapia, Santiago, Chile

[5] Clin Alemana Santiago, Dept Med Interna, Unidad Cuidados Intens, Santiago, Chile

来源：

关键词：

COVID-19;

D O I：

10.1016/j.clim.2020.108539

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

引用

页数：2

共 14 条

[1] Canaud G, 2014, NEW ENGL J MED, V371, P303, DOI [10.1056/NEJMoa1312890, 10.1056/NEJMc1410247]
[2] Cao B, 2020, NEW ENGL J MED, V382, P1787, DOI [10.1056/NEJMoa2001282, 10.1056/NEJMc2008043]
[3] COVID-19: Immunology and treatment options
Felsenstein, Susanna
Herbert, Jenny A.
McNamara, Paul S.
Hedrich, Christian M.
[J]. CLINICAL IMMUNOLOGY, 2020, 215
[4] Developmental and Functional Heterogeneity of Monocytes
Guilliams, Martin
Mildner, Alexander
Yona, Simon
[J]. IMMUNITY, 2018, 49 (04) : 595 - 613
[5] Harzallah I, 2020, J THROMB HAEMOST, V18, P2064, DOI [10.1111/jth.14867, 10.1111/jth.14980]
[6] Huang CL, 2020, LANCET, V395, P497, DOI [10.1016/S0140-6736(20)30211-7, 10.1016/S0140-6736(20)30183-5]
[7] Karsulovic C., 2020, BIORXIV, DOI [10.1101/2020.05.04.077537., DOI 10.1101/2020.05.04.077537]
[8] Tocilizumab treatment in COVID-19: A single center experience
Luo, Pan
Liu, Yi
Qiu, Lin
Liu, Xiulan
Liu, Dong
Li, Juan
[J]. JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (07) : 814 - 818
[9] COVID-19: consider cytokine storm syndromes and immunosuppression
Mehta, Puja
McAuley, Daniel F.
Brown, Michael
Sanchez, Emilie
Tattersall, Rachel S.
Manson, Jessica J.
[J]. LANCET, 2020, 395 (10229) : 1033 - 1034
[10] Mendy Angelico, 2020, medRxiv, DOI 10.1101/2020.06.25.20137323