FGFR Fusions in Cancer: From Diagnostic Approaches to Therapeutic Intervention

被引：92

作者：

De Luca, Antonella ^{[1
]}

Esposito Abate, Riziero ^{[1
]}

Rachiglio, Anna Maria ^{[1
]}

Maiello, Monica Rosaria ^{[1
]}

Esposito, Claudia ^{[1
]}

Schettino, Clorinda ^{[2
]}

Izzo, Francesco ^{[3
]}

Nasti, Guglielmo ^{[4
]}

Normanno, Nicola ^{[1
]}

机构：

[1] Ist Nazl Tumori IRCCS Fdn G Pascale, Cell Biol & Biotherapy Unit, I-80131 Naples, Italy

[2] Ist Nazl Tumori IRCCS Fdn G Pascale, Clin Trials Unit, I-80131 Naples, Italy

[3] Ist Nazl Tumori IRCCS Fdn G Pascale, Hepatobiliary Unit, Div Surg Oncol, I-80131 Naples, Italy

[4] Ist Nazl Tumori IRCCS Fdn G Pascale, SSD Innovat Therapies Abdominal Canc, I-80131 Naples, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 18期

关键词：

fibroblast growth factor receptors; FGFR fusions; next generation sequencing; cancer; FGFR inhibitors; GROWTH-FACTOR RECEPTOR; UNIQUE MOLECULAR SUBTYPE; GENE FUSIONS; UROTHELIAL CARCINOMA; TARGETED THERAPY; OPEN-LABEL; PHASE-II; IDENTIFICATION; MUTATIONS; CHOLANGIOCARCINOMA;

D O I：

10.3390/ijms21186856

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fibroblast growth factor receptors (FGFRs) are tyrosine kinase receptors involved in many biological processes. Deregulated FGFR signaling plays an important role in tumor development and progression in different cancer types.FGFRgenomic alterations, includingFGFRgene fusions that originate by chromosomal rearrangements, represent a promising therapeutic target. Next-generation-sequencing (NGS) approaches have significantly improved the discovery ofFGFRgene fusions and their detection in clinical samples. A variety of FGFR inhibitors have been developed, and several studies are trying to evaluate the efficacy of these agents in molecularly selected patients carryingFGFRgenomic alterations. In this review, we describe the most frequentFGFRaberrations in human cancer. We also discuss the different approaches employed for the detection ofFGFRfusions and the potential role of these genomic alterations as prognostic/predictive biomarkers.

引用

页码：1 / 18

页数：18

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