Deep brain stimulation for Parkinson's disease: defining the optimal location within the subthalamic nucleus

被引:69
作者
Bot, Maarten [1 ]
Schuurman, P. Richard [1 ]
Odekerken, Vincent J. J. [2 ]
Verhagen, Rens [1 ,2 ]
Contarino, Fiorella Maria [2 ,3 ,4 ]
De Bie, Rob M. A. [2 ]
van den Munckhof, Pepijn [1 ]
机构
[1] Acad Med Ctr, Dept Neurosurg, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
[2] Acad Med Ctr, Dept Neurol & Clin Neurophysiol, Amsterdam, Netherlands
[3] Leiden Univ, Dept Neurol, Med Ctr, Leiden, Netherlands
[4] Haga Teaching Hosp, Dept Neurol, The Hague, Netherlands
关键词
GLOBUS-PALLIDUS; FOLLOW-UP; MULTICENTER;
D O I
10.1136/jnnp-2017-316907
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background Individual motor improvement after deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) varies considerably. Stereotactic targeting of the dorsolateral sensorimotor part of the STN is considered paramount for maximising effectiveness, but studies employing the midcommissural point (MCP) as anatomical reference failed to show correlation between DBS location and motor improvement. The medial border of the STN as reference may provide better insight in the relationship between DBS location and clinical outcome. Methods Motor improvement after 12 months of 65 STN DBS electrodes was categorised into non-responding, responding and optimally responding body-sides. Stereotactic coordinates of optimal electrode contacts relative to both medial STN border and MCP served to define theoretic DBS 'hotspots'. Results Using the medial STN border as reference, significant negative correlation (Pearson's correlation -0.52, P<0.01) was found between the Euclidean distance from the centre of stimulation to this DBS hotspot and motor improvement. This hotspot was located at 2.8 mm lateral, 1.7 mm anterior and 2.5 mm superior relative to the medial STN border. Using MCP as reference, no correlation was found. Conclusion The medial STN border proved superior compared with MCP as anatomical reference for correlation of DBS location and motor improvement, and enabled defining an optimal DBS location within the nucleus. We therefore propose the medial STN border as a better individual reference point than the currently used MCP on preoperative stereotactic imaging, in order to obtain optimal and thus less variable motor improvement for individual patients with PD following STN DBS.
引用
收藏
页码:493 / 498
页数:6
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