Green Asparagus (Asparagus officinalis) Prevented Hypertension by an Inhibitory Effect on Angiotensin-Converting Enzyme Activity in the Kidney of Spontaneously Hypertensive Rats

被引：21

作者：

Sanae, Matsuda ^{[1
]}

Yasuo, Aoyagi ^{[2
]}

机构：

[1] Kagawa Nutr Univ, Jr Coll, Dept Food & Nutr, Toshima Ku, Tokyo 1708481, Japan

[2] Kagawa Nutr Univ, Dept Appl Nutr, Sakado, Saitama 3500288, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2013年 / 61卷 / 23期

关键词：

green asparagus; ACE inhibitor; hypertension; SHR; 2 ''-hydroxynicotianamine; BLOOD-PRESSURE; NICOTIANAMINE; BUCKWHEAT; PURIFICATION; SYSTEM;

D O I：

10.1021/jf3041066

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Green asparagus (Asparagus officinalis) is known to be rich in functional components. In the present study, spontaneously hypertensive rats (SHR) were used to clarify whether green asparagus prevents hypertension by inhibition of angiotensin-converting enzyme (ACE) activity. Six-week-old male SHR were fed a diet with (AD group) or without (ND group) 5% asparagus for 10 weeks. Systolic blood pressure (SBP) (AD: 159 +/- 4.8 mmHg, ND: 192 +/- 14.7 mmHg), urinary protein excretion/creatinine excretion, and ACE activity in the kidney were significantly lower in the AD group compared with the ND group. Creatinine clearance was significantly higher in the AD group compared with the ND group. In addition, ACE inhibitory activity was observed in a boiling water extract of asparagus. The ACE inhibitor purified and isolated from asparagus was identified as 2 ''-hydroxynicotianamine. In conclusion, 2 ''-hydroxynicotianamine in asparagus may be one of the factors inhibiting ACE activity in the kidney, thus preventing hypertension and preserving renal function.

引用

页码：5520 / 5525

页数：6

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