Epicardial Adipose Tissue and Cardiovascular Disease

被引：72

作者：

Le Jemtel, Thierry H. ^{[1
,2
]}

Samson, Rohan ^{[1
,2
]}

Ayinapudi, Karnika ^{[1
,2
]}

Singh, Twinkle ^{[1
,2
]}

Oparil, Suzanne ^{[3
]}

机构：

[1] Tulane Univ, Sch Med, Cardiol Sect, Dept Med, 1430 Tulane Ave,SL-48, New Orleans, LA 70112 USA

[2] Tulane Univ, Inst Heart & Vasc, 1430 Tulane Ave,SL-48, New Orleans, LA 70112 USA

[3] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Vasc Biol & Hypertens Program, Birmingham, AL 35294 USA

来源：

CURRENT HYPERTENSION REPORTS | 2019年 / 21卷 / 05期

关键词：

Epicardial adipose tissue; Coronary artery disease; Atrial fibrillation; Heart failure with preserved ejection fraction; CORONARY-ARTERY-DISEASE; PRESERVED EJECTION FRACTION; ONSET ATRIAL-FIBRILLATION; PERICARDIAL FAT VOLUME; VISCERAL ABDOMINAL FAT; BARIATRIC SURGERY; HEART-FAILURE; RISK-FACTORS; ECTOPIC FAT; MYOCARDIAL-ISCHEMIA;

D O I：

10.1007/s11906-019-0939-6

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Purpose of ReviewEpicardial adipose tissue has been associated with the development/progression of cardiovascular disease. We appraise the strength of the association between epicardial adipose tissue and development/progression of cardiovascular diseases like coronary artery disease, atrial fibrillation, and heart failure with preserved ejection fraction.Recent FindingsCross-sectional clinical and translational correlative studies have established an association between epicardial adipose tissue and progression of coronary artery disease. Recent studies question this association and underline the need for longitudinal studies. Epicardial adipose tissue also plays a definite role in the pathobiology of atrial fibrillation and its recurrence after ablation. In contrast to an early paradigm, epicardial adipose tissue does not appear to play a key role in the pathogenesis of heart failure with preserved ejection fraction in obese patients.SummaryThe association of epicardial adipose tissue with atrial fibrillation is robust. In contrast, the association of epicardial adipose tissue with coronary artery disease and heart failure with preserved ejection fraction is tenuous. Additional research, including longitudinal studies, is needed to confirm or refute these proposed associations.

引用

页数：11