Zika Virus Infection and Guillain-Barre Syndrome in Three Patients from Suriname

被引:16
作者
Langerak, Thomas [1 ]
Yang, Harvey [2 ]
Baptista, Mark [3 ]
Doornekamp, Laura [1 ]
Kerkman, Tessa [1 ]
Codrington, John [4 ]
Roosblad, Jimmy [4 ]
Vreden, Stephen G. S. [5 ]
De Bruin, Erwin [1 ]
Mogling, Ramona [1 ]
Jacobs, Bart C. [6 ,7 ]
Pas, Suzan D. [1 ]
GeurtsvanKessel, Corine H. [1 ]
Reusken, Chantal B. E. M. [1 ]
Koopmans, Marion P. [1 ]
Van Gorp, Eric C. M. [1 ]
Alberga, Henk [2 ]
机构
[1] Erasmus MC, Dept Virosci, Rotterdam, Netherlands
[2] Acad Hosp Paramaribo, Dept Neurol, Paramaribo, Suriname
[3] St Vincentius Hosp, Dept Neurol, Paramaribo, Suriname
[4] Acad Hosp Paramaribo, Diagnost Lab, Paramaribo, Suriname
[5] Acad Hosp Paramaribo, Dept Internal Med, Paramaribo, Suriname
[6] Erasmus MC, Dept Neurol, Rotterdam, Netherlands
[7] Erasmus MC, Dept Immunol, Rotterdam, Netherlands
来源
FRONTIERS IN NEUROLOGY | 2016年 / 7卷
关键词
Zika virus; Guillain-Barre syndrome; Flavivirus infections; acute flaccid paralysis; emerging infectious disease; VALIDATION;
D O I
10.3389/fneur.2016.00233
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We present three patients from Suriname who were diagnosed with Guillain-Barre syndrome (GBS) during the Zika virus (ZIKV) outbreak in this country. One patient had a positive ZIKV urine real-time RT-PCR (qRT-PCR) result. The other two patients had a negative ZIKV urine qRT-PCR but a positive virus neutralization test and presence of IgG antibodies against ZIKV in the serum. Considering the evidence of a past ZIKV infection and absence of evidence for recent infections with the most common preceding infections of GBS, it is very likely that these GBS cases were triggered by ZIKV.
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页数:5
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