Bacterium Induces Cryptic Meroterpenoid Pathway in the Pathogenic Fungus Aspergillus fumigatus

被引：117

作者：

Koenig, Claudia C. ^{[1
]}

Scherlach, Kirstin ^{[1
,2
]}

Schroeckh, Volker

Horn, Fabian ^{[3
]}

Nietzsche, Sandor ^{[4
]}

Brakhage, Axel A. ^{[1
,5
]}

Hertweck, Christian ^{[2
,5
]}

机构：

[1] Leibniz Inst Nat Prod Res & Infect Biol, Dept Mol & Appl Microbiol, D-07745 Jena, Germany

[2] Leibniz Inst Nat Prod Res & Infect Biol HKI, Dept Biomol Chem, D-07745 Jena, Germany

[3] Leibniz Inst Nat Prod Res & Infect Biol HKI, Res Grp Syst Biol Bioinformat, D-07745 Jena, Germany

[4] Jena Univ Hosp, Ctr Electron Microscopy, D-07743 Jena, Germany

[5] Univ Jena, Jena, Germany

来源：

CHEMBIOCHEM | 2013年 / 14卷 / 08期

关键词：

epigenetics; fumicyclines; genomics; microbial interactions; polyketides; Streptomyces; NATURAL-PRODUCT; GENE CLUSTERS; BIOSYNTHESIS; VIRULENCE; NIDULANS; VIRIDICATUMTOXIN; IDENTIFICATION; ANTIFUNGAL; GLIOTOXIN; NIGER;

D O I：

10.1002/cbic.201300070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stimulating encounter: The intimate, physical interaction between the soil-derived bacterium Streptomyces rapamycinicus and the human pathogenic fungus Aspergillus fumigatus led to the activation of an otherwise silent polyketide synthase (PKS) gene cluster coding for an unusual prenylated polyphenol (fumicycline A). The meroterpenoid pathway is regulated by a pathway-specific activator gene as well as by epigenetic factors. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：938 / 942

页数：5

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