Histone methylation in transcriptional control

被引：724
作者：
Kouzarides, T
机构：
[1] Univ Cambridge, Wellcome CRC Inst, Cambridge CB2 1QR, England
[2] Univ Cambridge, Dept Pathol, Cambridge CB2 1QR, England
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 02期
关键词：
D O I：
10.1016/S0959-437X(02)00287-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Over the past year or so, methylation of histories has come to be recognised as a major player in the regulation of gene activity. This notion follows the discovery of lysine and arginine methyltransferases and proteins that recognise the methyllysine 'mark' on histories. Methylated histories have been implicated in heterochromatic repression, promoter regulation and the propagation of a repressed state via DNA methylation.
引用
收藏
页码：198 / 209
页数：12
相关论文
共 76 条
  • [1] Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31
    Aagaard, L
    Laible, G
    Selenko, P
    Schmid, M
    Dorn, R
    Schotta, G
    Kuhfittig, S
    Wolf, A
    Lebersorger, A
    Singh, PB
    Reuter, G
    Jenuwein, T
    [J]. EMBO JOURNAL, 1999, 18 (07) : 1923 - 1938
  • [2] NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines
    Angrand, PO
    Apiou, F
    Stewart, AF
    Dutrillaux, B
    Losson, R
    Chambon, P
    [J]. GENOMICS, 2001, 74 (01) : 79 - 88
  • [3] Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin
    Bachman, KE
    Rountree, MR
    Baylin, SB
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (34) : 32282 - 32287
  • [4] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    Bannister, AJ
    Zegerman, P
    Partridge, JF
    Miska, EA
    Thomas, JO
    Allshire, RC
    Kouzarides, T
    [J]. NATURE, 2001, 410 (6824) : 120 - 124
  • [5] Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers
    Bantignies, F
    Goodman, RH
    Smolik, SM
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (24) : 9317 - 9330
  • [6] BAUER UT, 2002, IN PRESS EMBO REPORT
  • [7] Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains
    Bedford, MT
    Frankel, A
    Yaffe, MB
    Clarke, S
    Leder, P
    Richard, S
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (21) : 16030 - 16036
  • [8] The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies
    Brahms, H
    Raymackers, J
    Union, A
    de Keyser, F
    Meheus, L
    Lührmann, R
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (22) : 17122 - 17129
  • [9] Retinoblastoma protein meets chromatin
    Brehm, A
    Kouzarides, T
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (04) : 142 - 145
  • [10] Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae
    Briggs, SD
    Bryk, M
    Strahl, BD
    Cheung, WL
    Davie, JK
    Dent, SYR
    Winston, F
    Allis, CD
    [J]. GENES & DEVELOPMENT, 2001, 15 (24) : 3286 - 3295
12345678