Functional abnormalities and changes in gene expression in fibroblasts and macrophages from the bone marrow of patients with acute myeloid leukemia

被引：7
|
作者：
Li, Yu [1 ]
Durig, Jan [1 ]
Goebel, Maria [1 ]
Hanoun, Maher [1 ]
Klein-Hitpass, Ludger [2 ]
Duehrsen, Ulrich [1 ]
机构：
[1] Univ Hosp Essen, Dept Hematol, D-45147 Essen, Germany
[2] Univ Hosp Essen, Inst Cell Biol, D-45147 Essen, Germany
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2015年 / 102卷 / 03期
关键词：
Acute myeloid leukemia; Fibroblast; Long-term bone marrow culture; Macrophage; Stroma; HEMATOPOIETIC STEM-CELLS; STROMAL CELLS; PROGENITOR CELLS; MYELODYSPLASTIC SYNDROME; CLONAL HEMATOPOIESIS; SELF-RENEWAL; CANCER; INVITRO; MICROENVIRONMENT; PROLIFERATION;
D O I：
10.1007/s12185-015-1833-x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In bone marrow malignancies, little is known about the fate of stromal cells after replacement of normal cells by neoplastic hematopoietic ones. In this study, fibroblasts from patients with acute myeloid leukemia or myelodysplastic syndromes exhibited a significantly lower ability to support hematopoiesis originating from co-cultured allogeneic CD34-positive cells than did fibroblasts from healthy marrow. Conversely, macrophages from acute myeloid leukemia marrow significantly enhanced the production of blood cells compared with control macrophages. Aberrant function was associated with consistent changes in the expression of genes involved in hematopoietic stem cell control, such as cytokines and regulators of the Wnt signaling pathway.
引用
收藏
页码：278 / 288
页数：11
相关论文
共 50 条
  • [31] Epigenetic Silencing of Immune-Checkpoint Receptors in Bone Marrow- Infiltrating T Cells in Acute Myeloid Leukemia
    Radpour, Ramin
    Stucki, Miriam
    Riether, Carsten
    Ochsenbein, Adrian F.
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [32] Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapy
    Radujkovic, Aleksandar
    Dietrich, Sascha
    Andrulis, Mindaugas
    Benner, Axel
    Longerich, Thomas
    Pellagatti, Andrea
    Nanda, Kriti
    Giese, Thomas
    Germing, Ulrich
    Baldus, Stefan
    Boultwood, Jacqueline
    Ho, Anthony D.
    Dreger, Peter
    Luft, Thomas
    INTERNATIONAL JOURNAL OF CANCER, 2016, 139 (06) : 1402 - 1413
  • [33] Cytokines, growth, and environment factors in bone marrow plasma of acute lymphoblastic leukemia pediatric patients
    Kovac, Martin
    Vaskova, Martina
    Petrackova, Denisa
    Pelkova, Vendula
    Mejstrikova, Ester
    Kalina, Tomas
    Zaliova, Marketa
    Weiser, Jaroslav
    Stary, Jan
    Hrusak, Ondrej
    EUROPEAN CYTOKINE NETWORK, 2014, 25 (01) : 8 - 13
  • [34] Expression of matrix metalloproteinase and their inhibitors in the bone marrow of patients with acute leukemia
    Gaidamaka, N. V.
    Parovichnikova, E. N.
    Zavalishina, L. E.
    Savchenko, V. G.
    Frank, G. A.
    GEMATOLOGIYA I TRANSFUZIOLOGIYA, 2009, 54 (02): : 3 - 10
  • [35] Acute Myeloid Leukaemia Drives Metabolic Changes in the Bone Marrow Niche
    Maynard, Rebecca S.
    Hellmich, Charlotte
    Bowles, Kristian M.
    Rushworth, Stuart A.
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [36] Bone marrow fibrosis at diagnosis predicts survival for primary acute myeloid leukemia
    Wu, Z.
    Chen, R.
    Wu, L.
    Zou, L.
    Ding, F.
    Wang, M.
    Liu, X.
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2017, 19 (12) : 1462 - 1468
  • [37] Inhibition of TGF-(3 signaling in bone marrow endothelial cells promotes hematopoietic recovery in acute myeloid leukemia patients
    Wang, Zhen-Kun
    Zhang, Zhi-Wei
    Lyu, Zhong-Shi
    Xing, Tong
    Liang, Mi
    Shen, Meng-Zhu
    Li, Chen-Yuan
    Zhang, Xin-Yan
    Chen, Dan-Dan
    Wang, Ya-Zhe
    Hu, Li-Juan
    Jiang, Hao
    Wang, Yu
    Jiang, Qian
    Zhang, Xiao-Hui
    Kong, Yuan
    Huang, Xiao-Jun
    CANCER LETTERS, 2024, 605
  • [38] Study of Bone Marrow Lymphocyte Subset in Acute Myeloid Leukemia
    Dange, Prasad
    Tyagi, Seema
    Juneja, Richa
    Seth, Tulika
    Saxena, Renu
    JOURNAL OF LABORATORY PHYSICIANS, 2022, 14 (02) : 151 - 156
  • [39] The immunometabolic landscape of the bone marrow microenvironment in acute myeloid leukemia
    Xu, Binyan
    Zhou, Ziying
    Wen, Yueting
    Li, Zhongwei
    Huang, Zhongxi
    Li, Yuhua
    EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022, 11 (01)
  • [40] Gene expression and prognosis in acute myeloid leukemia
    Bullinger, L.
    Doehner, K.
    Frohling, St.
    Schlenk, R. F.
    Pollack, J. R.
    Doehner, H.
    ANNALS OF HEMATOLOGY, 2008, 87 : S35 - S37
12345