Functional abnormalities and changes in gene expression in fibroblasts and macrophages from the bone marrow of patients with acute myeloid leukemia

被引：7
|
作者：
Li, Yu [1 ]
Durig, Jan [1 ]
Goebel, Maria [1 ]
Hanoun, Maher [1 ]
Klein-Hitpass, Ludger [2 ]
Duehrsen, Ulrich [1 ]
机构：
[1] Univ Hosp Essen, Dept Hematol, D-45147 Essen, Germany
[2] Univ Hosp Essen, Inst Cell Biol, D-45147 Essen, Germany
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2015年 / 102卷 / 03期
关键词：
Acute myeloid leukemia; Fibroblast; Long-term bone marrow culture; Macrophage; Stroma; HEMATOPOIETIC STEM-CELLS; STROMAL CELLS; PROGENITOR CELLS; MYELODYSPLASTIC SYNDROME; CLONAL HEMATOPOIESIS; SELF-RENEWAL; CANCER; INVITRO; MICROENVIRONMENT; PROLIFERATION;
D O I：
10.1007/s12185-015-1833-x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In bone marrow malignancies, little is known about the fate of stromal cells after replacement of normal cells by neoplastic hematopoietic ones. In this study, fibroblasts from patients with acute myeloid leukemia or myelodysplastic syndromes exhibited a significantly lower ability to support hematopoiesis originating from co-cultured allogeneic CD34-positive cells than did fibroblasts from healthy marrow. Conversely, macrophages from acute myeloid leukemia marrow significantly enhanced the production of blood cells compared with control macrophages. Aberrant function was associated with consistent changes in the expression of genes involved in hematopoietic stem cell control, such as cytokines and regulators of the Wnt signaling pathway.
引用
收藏
页码：278 / 288
页数：11
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