Epigallocatechin-3-gallate combined with alpha lipoic acid attenuates high glucose-induced receptor for advanced glycation end products (RAGE) expression in human embryonic kidney cells

被引：19
|
作者：
Leu, Jyh-Gang [1 ,2 ]
Lin, Chin-Yao [2 ]
Jian, Jhin-Hao [3 ]
Shih, Chin-Yu [4 ]
Liang, Yao-Jen [3 ]
机构：
[1] Fu Jen Catholic Univ, Sch Med, New Taipei City 24205, Taiwan
[2] Shin Kong Wu Ho Su Mem Hosp, Dept Internal Med, Div Nephrol, Taipei 11101, Taiwan
[3] Fu Jen Catholic Univ, Dept & Inst Life Sci, New Taipei City 24205, Taiwan
[4] Dev Ctr Biotechnol, Dept Anim Pharmacol, New Taipei City 22160, Taiwan
来源：
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2013年 / 85卷 / 02期
关键词：
diabetic nephropathy; receptor of advanced glycation end products; epigallocatechin gallate; alpha lipoic acid; anti-oxidant; TEA POLYPHENOL (-)-EPIGALLOCATECHIN-3-GALLATE; DIABETIC VASCULAR COMPLICATIONS; GREEN TEA; OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; NEPHROPATHY; EGCG; RATS; ERYTHROCYTES; REDUCTION;
D O I：
10.1590/S0001-37652013005000023
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The anti-oxidant effects of epigallocatechin gallate (EGCG) and alpha lipoic acid (ALA) have been demonstrated in previous studies. The kidney protection effects of EGCG and ALA in patients with kidney injury are still under investigation. The purpose of this study is to investigate the anti-inflammatory and anti-oxidant effects of EGCG and ALA on high glucose-induced human kidney cell damage. EGCG inhibited high glucose(HG)-induced TNF-alpha and IL-6 production in human embryonic kidney (HEK) cells. Both EGCG and ALA decreased HG-induced receptor of advanced glycation end products (RAGE) mRNA and protein expressions in HEK cells. EGCG and ALA also recovered HG-inhibited superoxide dismutase production and decreased ROS expressions in HEK cells. The synergism of EGCG and ALA was also studied. The effect of EGCG combined with ALA is greater than the effect of EGCG alone in all anti-inflammation and anti-oxidant experiments. Our studies provide a potential therapeutic application of EGCG and ALA in preventing progression of diabetic nephropathy.
引用
收藏
页码：745 / 752
页数：8
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