Serum vascular endothelial growth factor: a prognostic factor in cervical cancer

被引：28

作者：

Zusterzeel, Petra L. M. ^{[2
]}

Span, Paul N. ^{[1
]}

Dijksterhuis, Marja G. K. ^{[2
]}

Thomas, Chris M. G. ^{[1
,2
]}

Sweep, Fred C. G. J. ^{[1
]}

Massuger, Leon F. A. G. ^{[2
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Chem Endocrinol 479, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Obstet & Gynaecol, NL-6500 HB Nijmegen, Netherlands

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2009年 / 135卷 / 02期

关键词：

Angiogenesis; VEGF; Vascular endothelial growth factor; Cervical cancer; Prognostic value; Survival; FACTOR VEGF; STAGE IB; MICROVESSEL DENSITY; TUMOR ANGIOGENESIS; CARCINOMA; EXPRESSION; RADIOTHERAPY; BIOLOGY;

D O I：

10.1007/s00432-008-0442-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To study pre-treatment serum VEGF of patients with invasive cervical cancer and its possible role as prognostic indicator. VEGF was measured using ELISA in the largest patient group (n = 167) to date. Serum VEGF was significantly higher in advanced tumor stage (P = 0.01), large tumor size (tumors larger than 2 cm) (P = 0.03), and the presence of vascular space invasion (P = 0.05). Serum VEGF was associated with disease free and overall survival [DFS: Hazard Ratio (HR) = 2.61; 95% CI 1.32-5.17; P = 0.006; for OS: HR = 2.09; 95% CI 1.54-2.84; P < 0.001, respectively]. In multivariate Cox regression serum VEGF retained its prognostic value for DFS (HR = 2.10, P = 0.03) and OS (HR = 1.92, P = 0.04). Serum VEGF levels correlate with more advanced and more aggressive disease in cervical cancer and may be a useful prognostic factor in patients with cervical cancer.

引用

页码：283 / 290

页数：8

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