Molecular and physiological insights into plague transmission, virulence and etiology

被引：42

作者：

Zhou, DS ^{[1
]}

Han, YP ^{[1
]}

Yang, RF ^{[1
]}

机构：

[1] Acad Mil Med Sci, Inst Microbiol & Epidemiol, Army Ctr Microbial Detect & Res, Natl Ctr Biomed Anal,State Key Lab Pathogen & Bio, Beijing 100071, Peoples R China

来源：

MICROBES AND INFECTION | 2006年 / 8卷 / 01期

关键词：

Yersinia pestis; plague; transmission; pathogenesis; virulence determinants; genomics;

D O I：

10.1016/j.micinf.2005.06.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plague is caused by Yersinia pestis, which evolved from the enteric pathogen Y. pseudotuberculosis, which normally causes a chronic and relatively mild disease. Y. pestis is not only able to parasitize the flea but also highly virulent to rodents and humans, causing epidemics of a systemic and often fatal disease. Y. pestis could be used as a bio-weapon and for bio-terrorism. It uses a number of strategies that allow the pathogen to change its lifestyle rapidly to survive in fleas and to grow in the mammalian hosts. Extensive studies reviewed here give an overall picture of the determinants responsible for plague pathogenesis in mammalians and the transmission by fleas. The availability of multiple genomic sequences and more extensive use of genomics and proteomics technologies should allow a comprehensive dissection of the complex of host-adaptation and virulence in Y. pestis. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：273 / 284

页数：12

共 130 条

[11] How to survive in the host:: the Yersinia lesson [J].

Bleves, S ;

Cornelis, GR .

MICROBES AND INFECTION, 2000, 2 (12) :1451-1460

[12] The Yersinia high-pathogenicity island:: an iron-uptake island [J].

Carniel, E .

MICROBES AND INFECTION, 2001, 3 (07) :561-569

[13]

CAVANAUGH DC, 1959, J IMMUNOL, V83, P348

[14] Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis [J].

Chain, PSG ;

Carniel, E ;

Larimer, FW ;

Lamerdin, J ;

Stoutland, PO ;

Regala, WM ;

Georgescu, AM ;

Vergez, LM ;

Land, ML ;

Motin, VL ;

Brubaker, RR ;

Fowler, J ;

Hinnebusch, J ;

Marceau, M ;

Medigue, C ;

Simonet, M ;

Chenal-Francisque, V ;

Souza, B ;

Dacheux, D ;

Elliott, JM ;

Derbise, A ;

Hauser, LJ ;

Garcia, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (38) :13826-13831

[15] Structural and functional significance of the FGL sequence of the periplasmic chaperone Caf1M of Yersinia pestis [J].

Chapman, DAG ;

Zavialov, AV ;

Chernovskaya, TV ;

Karlyshev, AV ;

Zav'yalova, GA ;

Vasiliev, AM ;

Dudich, IV ;

Abramov, VM ;

Zav'yalov, VP ;

MacIntyre, S .

JOURNAL OF BACTERIOLOGY, 1999, 181 (08) :2422-2429

[16] SURVIVAL AND GROWTH OF YERSINIA-PESTIS WITHIN MACROPHAGES AND AN EFFECT OF THE LOSS OF THE 47-MEGADALTON PLASMID ON GROWTH IN MACROPHAGES [J].

CHARNETZKY, WT ;

SHUFORD, WW .

INFECTION AND IMMUNITY, 1985, 47 (01) :234-241

[17] The Yersinia YSC-YOP 'type III' weaponry [J].

Cornelis, GR .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (10) :742-752

[18] The virulence plasmid of Yersinia, an antihost genome [J].

Cornelis, GR ;

Boland, A ;

Boyd, AP ;

Geuijen, C ;

Iriarte, M ;

Neyt, C ;

Sory, MP ;

Stainier, I .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 1998, 62 (04) :1315-+

[19] Molecular and cell biology aspects of plague [J].

Cornelis, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) :8778-8783

[20] Invasion of epithelial cells by Yersinia pestis:: Evidence for a Y pestis-specific invasin [J].

Cowan, C ;

Jones, HA ;

Kaya, YH ;

Perry, RD ;

Straley, SC .

INFECTION AND IMMUNITY, 2000, 68 (08) :4523-4530

← 1 2 3 4 5 6 7 8 9 10 →