Molecular and physiological insights into plague transmission, virulence and etiology

被引：42

作者：

Zhou, DS ^{[1
]}

Han, YP ^{[1
]}

Yang, RF ^{[1
]}

机构：

[1] Acad Mil Med Sci, Inst Microbiol & Epidemiol, Army Ctr Microbial Detect & Res, Natl Ctr Biomed Anal,State Key Lab Pathogen & Bio, Beijing 100071, Peoples R China

来源：

MICROBES AND INFECTION | 2006年 / 8卷 / 01期

关键词：

Yersinia pestis; plague; transmission; pathogenesis; virulence determinants; genomics;

D O I：

10.1016/j.micinf.2005.06.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plague is caused by Yersinia pestis, which evolved from the enteric pathogen Y. pseudotuberculosis, which normally causes a chronic and relatively mild disease. Y. pestis is not only able to parasitize the flea but also highly virulent to rodents and humans, causing epidemics of a systemic and often fatal disease. Y. pestis could be used as a bio-weapon and for bio-terrorism. It uses a number of strategies that allow the pathogen to change its lifestyle rapidly to survive in fleas and to grow in the mammalian hosts. Extensive studies reviewed here give an overall picture of the determinants responsible for plague pathogenesis in mammalians and the transmission by fleas. The availability of multiple genomic sequences and more extensive use of genomics and proteomics technologies should allow a comprehensive dissection of the complex of host-adaptation and virulence in Y. pestis. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：273 / 284

页数：12

共 130 条

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