Synthesis and stability of S-(2-[18F]fluoroethyl)-L-homocysteine for potential tumour imaging

被引：10

作者：

Bourdier, Thomas ^{[1
]}

Fookes, Christopher J. R. ^{[1
]}

Pham, Tien Q. ^{[1
]}

Greguric, Ivan ^{[1
]}

Katsifis, Andrew ^{[1
]}

机构：

[1] Australian Nucl Sci & Technol Org, Radiopharmaceut Res Inst, Menai, NSW 2234, Australia

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2008年 / 51卷 / 11-12期

关键词：

S-(2-[F-18]fluoroethyl)-L-homocysteine; FEHCys; amino acids; nucleophilic [F-18]-fluorination;

D O I：

10.1002/jlcr.1539

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The F-18 labelled methionine derivative S-(2-[F-18]fluoroethyl)-L-homocysteine ([F-18]FEHCys) was prepared by a one-pot two-step synthesis via the protected S-(2-bromoethyl)-L-homocysteine 1 and S-(2-chloroethyl)-L-homocysteine 2 precursors. The bromoethyl derivative 1 gave higher radiochemical yields (40% at 5 min) at 100 degrees C compared with the chloro-analogue (22% at 100 C in 30 min). However, [F-18]FEHCys was found to be unstable in aqueous systems being transformed to the corresponding hydroxyl derivative within 20 min.

引用

页码：369 / 373

页数：5

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