The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

被引：1060

作者：

Kansanen, Emilia ^{[1
]}

Kuosmanen, Suvi M. ^{[1
]}

Leinonen, Hanna ^{[1
]}

Levonen, Anna-Liisa ^{[1
]}

机构：

[1] Univ Eastern Finland, AI Virtanen Inst Mol Sci, Dept Biotechnol & Mol Med, FIN-70211 Kuopio, Finland

来源：

REDOX BIOLOGY | 2013年 / 1卷 / 01期

基金：

芬兰科学院;

关键词：

Nrf2; Keap1; Cancer; Antioxidant response element; Gene therapy; NRF2; EFFICACY;

D O I：

10.1016/j.redox.2012.10.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Keap1-Nrf2 pathway is the major regulator of cytoprotective responses to oxidative and electrophilic stress. Although cell signaling pathways triggered by the transcription factor Nrf2 prevent cancer initiation and progression in normal and premalignant tissues, in fully malignant cells Nrf2 activity provides growth advantage by increasing cancer chemoresistance and enhancing tumor cell growth. In this graphical review, we provide an overview of the Keap1-Nrf2 pathway and its dysregulation in cancer cells. We also briefly summarize the consequences of constitutive Nrf2 activation in cancer cells and how this can be exploited in cancer gene therapy. (C) 2013 The Authors. Published by Elsevier B.V.

引用

页码：45 / 49

页数：5

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