Genetic Susceptibility to West Nile Virus and Dengue

被引：13
作者：
Loeb, M. [1 ]
机构：
[1] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8N 3Z5, Canada
来源：
PUBLIC HEALTH GENOMICS | 2013年 / 16卷 / 1-2期
关键词：
Epidemiology; Genetic; Genomic analysis of complex diseases; HEMORRHAGIC-FEVER; SHOCK SYNDROME; RISK-FACTOR; INFECTION; SEVERITY; ASSOCIATIONS; DEFICIENCY; DISEASE; ALLELE; HLA;
D O I：
10.1159/000345934
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
This article focuses on the host genetic predisposition to 2 viruses, West Nile virus and dengue virus, which belong to the genus Flavivirus. Although by definition these viruses have shared characteristics (e.g. similar size, single stranded, RNA viruses, both transmitted by the bite from an infected mosquito), they differ greatly in epidemiology and clinical manifestations. The text below not only summarizes the genetic factors that predispose to complications of these 2 important flaviviruses, but also illustrates the challenges in determining the genomic basis for complications to these viruses. Copyright (C) 2013 S. Karger AG, Basel
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页码：4 / 8
页数：5
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