Genetic Susceptibility to West Nile Virus and Dengue

被引:13
|
作者
Loeb, M. [1 ]
机构
[1] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8N 3Z5, Canada
关键词
Epidemiology; Genetic; Genomic analysis of complex diseases; HEMORRHAGIC-FEVER; SHOCK SYNDROME; RISK-FACTOR; INFECTION; SEVERITY; ASSOCIATIONS; DEFICIENCY; DISEASE; ALLELE; HLA;
D O I
10.1159/000345934
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
This article focuses on the host genetic predisposition to 2 viruses, West Nile virus and dengue virus, which belong to the genus Flavivirus. Although by definition these viruses have shared characteristics (e.g. similar size, single stranded, RNA viruses, both transmitted by the bite from an infected mosquito), they differ greatly in epidemiology and clinical manifestations. The text below not only summarizes the genetic factors that predispose to complications of these 2 important flaviviruses, but also illustrates the challenges in determining the genomic basis for complications to these viruses. Copyright (C) 2013 S. Karger AG, Basel
引用
收藏
页码:4 / 8
页数:5
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