Adipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease

被引：2

作者：

Schwerk, Anne ^{[1
]}

Altschueler, Jennifer ^{[1
]}

Roch, Manfred ^{[2
]}

Gossen, Manfred ^{[2
,3
]}

Winter, Christine ^{[4
]}

Berg, Juergen ^{[1
]}

Kurtz, Andreas ^{[2
,3
,5
,6
]}

Akyuez, Levent ^{[2
,7
]}

Steiner, Barbara ^{[1
]}

机构：

[1] Charite, Dept Neurol, D-13353 Berlin, Germany

[2] Berlin Brandenburg Ctr Regenerat Therapies BCRT, Berlin, Germany

[3] Helmholtz Zentrum Geesthacht HZG, Inst Biomat Sci, Teltow, Germany

[4] Tech Univ Dresden, Dept Psychiat, Dresden, Germany

[5] Seoul Natl Univ, Coll Vet Med, Seoul 157742, South Korea

[6] Seoul Natl Univ, Res Inst Vet Sci, Seoul 157742, South Korea

[7] Humboldt Univ, Bereich Med Charite, Inst Med Immunol, Berlin, Germany

来源：

REGENERATIVE MEDICINE | 2015年 / 10卷 / 04期

关键词：

adipose-derived mesenchymal stem cells; adult stem cells; neurogenesis; Parkinson's disease; plasticity; regeneration; MEDIAL FOREBRAIN-BUNDLE; BONE-MARROW; SUBSTANTIA-NIGRA; STROMAL CELLS; GROWTH-FACTOR; DOPAMINERGIC-NEURONS; SUBVENTRICULAR ZONE; CHOROID-PLEXUS; ADULT BRAIN; DIFFERENTIATION;

D O I：

10.2217/RME.15.17

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Background: Mesenchymal stem cells (MSC) are easily harvested, and possess anti-inflammatory and trophic properties. Furthermore, MSC promote neuroprotection and neurogenesis, which could greatly benefit neurodegenerative disorders, such as Parkinson's disease. Methods: MSC were transplanted one week after 6-hydroxydopamine lesioning and effects were evaluated after 6 months. Results: MSC localized around the substantia nigra and the arachnoid mater, expressing pericyte and endothelial markers. MSC protected dopamine levels and upregulated peripheral anti-inflammatory cytokines. Furthermore, adipose-derived MSC increased neurogenesis in hippocampal and subventricular regions, and boosted memory functioning. Conclusion: Considering that hyposmia and loss of memory function are two major nonmotor symptoms in Parkinson's disease, transplants with modulatory effects on the hippocampus and subventricular zone could provide a disease-modifying therapy.

引用

页码：431 / 446

页数：16

共 75 条

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