Pathophysiology of diabetic erectile dysfunction: potential contribution of vasa nervorum and advanced glycation endproducts

被引：40
作者：
Cellek, S. [1 ]
Cameron, N. E. [2 ]
Cotter, M. A. [2 ]
Muneer, A. [3 ]
机构：
[1] Cranfield Univ, Dept Translat Med, Cranfield Hlth, Cranfield MK43 0AL, Beds, England
[2] Univ Aberdeen, Sch Med Sci, Aberdeen, Scotland
[3] UCL, Inst Urol, London, England
来源：
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH | 2013年 / 25卷 / 01期
关键词：
advanced glycation endproducts; diabetes mellitus; erectile dysfunction; hypoxia; microvessel; nitric oxide; vasa nervorum; NITRIC-OXIDE SYNTHASE; ENDOTHELIUM-DEPENDENT VASODILATION; GANGLION BLOOD-FLOW; END-PRODUCTS; ELEVATED GLUCOSE; NERVE CONDUCTION; NITRERGIC NEUROPATHY; CEREBRAL-ARTERIES; OXIDATIVE STRESS; PENILE ERECTION;
D O I：
10.1038/ijir.2012.30
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Erectile dysfunction (ED) due to diabetes mellitus remains difficult to treat medically despite advances in pharmacotherapeutic approaches in the field. This unmet need has resulted in a recent re-focus on the pathophysiology, in order to understand the cellular and molecular mechanisms leading to ED in diabetes. Diabetes-induced ED is often resistant to PDE5 inhibitor treatment, thus there is a need to discover targets that may lead to novel approaches for a successful treatment. The aim of this brief review is to update the reader in some of the latest development on that front, with a particular focus on the role of impaired neuronal blood flow and the formation of advanced glycation endproducts. International Journal of Impotence Research (2013) 25, 1-6; doi:10.1038/ijir.2012.30; published online 23 August 2012
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页码：1 / 6
页数：6
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