Pathophysiology of diabetic erectile dysfunction: potential contribution of vasa nervorum and advanced glycation endproducts

被引：40

作者：

Cellek, S. ^{[1
]}

Cameron, N. E. ^{[2
]}

Cotter, M. A. ^{[2
]}

Muneer, A. ^{[3
]}

机构：

[1] Cranfield Univ, Dept Translat Med, Cranfield Hlth, Cranfield MK43 0AL, Beds, England

[2] Univ Aberdeen, Sch Med Sci, Aberdeen, Scotland

[3] UCL, Inst Urol, London, England

来源：

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH | 2013年 / 25卷 / 01期

关键词：

advanced glycation endproducts; diabetes mellitus; erectile dysfunction; hypoxia; microvessel; nitric oxide; vasa nervorum; NITRIC-OXIDE SYNTHASE; ENDOTHELIUM-DEPENDENT VASODILATION; GANGLION BLOOD-FLOW; END-PRODUCTS; ELEVATED GLUCOSE; NERVE CONDUCTION; NITRERGIC NEUROPATHY; CEREBRAL-ARTERIES; OXIDATIVE STRESS; PENILE ERECTION;

D O I：

10.1038/ijir.2012.30

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Erectile dysfunction (ED) due to diabetes mellitus remains difficult to treat medically despite advances in pharmacotherapeutic approaches in the field. This unmet need has resulted in a recent re-focus on the pathophysiology, in order to understand the cellular and molecular mechanisms leading to ED in diabetes. Diabetes-induced ED is often resistant to PDE5 inhibitor treatment, thus there is a need to discover targets that may lead to novel approaches for a successful treatment. The aim of this brief review is to update the reader in some of the latest development on that front, with a particular focus on the role of impaired neuronal blood flow and the formation of advanced glycation endproducts. International Journal of Impotence Research (2013) 25, 1-6; doi:10.1038/ijir.2012.30; published online 23 August 2012

引用

页码：1 / 6

页数：6

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